Phenotypes associated with this allele

• Allele Symbol: Gjd2^tm1Mony
• Allele Name: targeted mutation 1, Hannah Monyer
• Allele ID: MGI:2388290
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjd2^tm1Mony/Gjd2^tm1Mony	Not Specified	MGI:3810169

Genotype
MGI:3810169

hm1

• Allelic Composition: Gjd2^tm1Mony/Gjd2^tm1Mony
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:71116 )

N • mice exhibit normal high frequency rhythms and ripple activity in the hippocampi

abnormal action potential ( J:71116 )

• interneurons do not exhibit facilitation of action potential generations as in wild-type mice

abnormal brain wave pattern ( J:71116 )

• in response to kainite or carbachol, mice exhibit decreased amplitudes of gamma oscillation compared to wild-type mice

• pyramidal cells and interneurons exhibit reduced oscillatory power in the gamma frequency band compared to in wild-type mice

abnormal CNS synaptic transmission ( J:71116 )

• fast-spiking interneurons fail to exhibit reciprocal coupling unlike in wild-type mice

abnormal excitatory postsynaptic potential ( J:71116 )

• median excitatory postsynaptic potentials onto interneurons are greater than in wild-type mice

abnormal inhibitory postsynaptic potential ( J:71116 )

• inhibitory postsynaptic potentials (IPSPs) are disrupted in amplitude in pyramidal cells and rhythmicity in pyramidal cells and interneurons compared to in wild-type mice

• the incidence between IPSPs is increased compared to in wild-type mice