Phenotypes associated with this allele

• Allele Symbol: Dab1^tm2Cpr
• Allele Name: targeted mutation 2, Jonathan A Cooper
• Allele ID: MGI:2388292
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm2Cpr/Dab1^tm2Cpr	either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3722250
hm2	Dab1^tm2Cpr/Dab1^tm2Cpr	involves: 129S4/SvJaeSor	MGI:3810295
hm3	Dab1^tm2Cpr/Dab1^tm2Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3722179
ht4	Dab1^tm1Cpr/Dab1^tm2Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3722181

Genotype
MGI:3722250

hm1

• Allelic Composition: Dab1^tm2Cpr/Dab1^tm2Cpr
• Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal rostral migratory stream morphology ( J:121846 )

• at P17 and P61, rostral migratory streams of (RMS) neuroblasts are severely disrupted and neuroblasts accumulate in the subventricular zone

abnormal postnatal subventricular zone morphology ( J:121846 )

• neuroblasts accumulate in the subventricular zone

• a 15-fold increase in apoptosis in the subventricular zone is observed

Genotype
MGI:3810295

hm2

• Allelic Composition: Dab1^tm2Cpr/Dab1^tm2Cpr
• Genetic Background: involves: 129S4/SvJaeSor

nervous system

abnormal cortical marginal zone morphology ( J:74239 )

• the neocortical marginal zone is crowded with polymorphic cells unlike in wild-type mice

abnormal dentate gyrus morphology ( J:74239 )

• the dentate gyrus is disrupted

abnormal hippocampus pyramidal cell layer ( J:74239 )

• the pyramidal cells are scattered over a broad region unlike in wild-type mice

Genotype
MGI:3722179

hm3

• Allelic Composition: Dab1^tm2Cpr/Dab1^tm2Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

mortality/aging

premature death ( J:79475 )

• mice die at day 20 to 30 of unidentified causes

nervous system

abnormal brain morphology ( J:79475 )

• the cerebral cortex, hippocampus and cerebellum exhibit defects

abnormal cortical marginal zone morphology ( J:79475 )

• the cortical marginal zone is occupied with many cells unlike in wild-type mice

• the intermediate plexiform zone proximal to the pial surface contains ectopic nerve tracts

absent cerebellar foliation ( J:79475 )

abnormal hippocampus CA2 region morphology ( J:79475 )

• only two or three wavy lamina form

abnormal dentate gyrus morphology ( J:79475 )

• the granule cells in the dentate gyrus are disorganized

abnormal cerebral cortex morphology ( J:79475 )

• the six layers of the cerebral cortex are disorganized

abnormal cerebellar Purkinje cell layer ( J:79475 )

• the Purkinje cell layers are organized into internal clusters

abnormal cerebellar granule layer morphology ( J:79475 )

• the cerebellar granule cells are found in a less organized layer than in wild-type mice and are excluded from the external limits of the cerebellum by a thin molecular layer

small cerebellum ( J:79475 )

• the cerebellum is one fifth the size of that in normal mice

behavior/neurological

ataxia ( J:79475 )

• mice display ataxia that is characterized by frequent loss of balance, tremulous locomotion, tendency to drag hind limbs and hyperextension of the tail

impaired balance ( J:79475 )

abnormal tail movements ( J:79475 )

• ataxic mice often display hyperextension of the tail

Genotype
MGI:3722181

ht4

• Allelic Composition: Dab1^tm1Cpr/Dab1^tm2Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

behavior/neurological

ataxia ( J:79475 )

• authors state that mice exhibit the same ataxic phenotype as Dab1^tm2Cpr homozygotes