All Phenotypes Cd79a<tm1.1Cgn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd79a^tm1.1Cgn
targeted mutation 1.1, University of Cologne
MGI:2388326

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn	involves: 129P2/OlaHsd	MGI:3722628
hm2	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3813546
cx3	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129P2/OlaHsd	MGI:5301878
cx4	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b⁺	involves: 129P2/OlaHsd	MGI:5301880
cx5	Cd79a^tm1.1Cgn/Cd79a⁺ Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129P2/OlaHsd	MGI:5301881
cx6	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3813551
cx7	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm3Mnz/Cd79b^tm3Mnz	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3768661
cx8	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3722627

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B-1a cell number ( J:124400 )

immune system

decreased B-1a cell number ( J:124400 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:71100 )

• there is about a 30% reduction in the number of recirculating B cells found in the bone marrow

decreased B-1 B cell number ( J:71100 )

• B-1 B cells numbers are reduced by 10-fold in the peritoneum

decreased marginal zone B cell number ( J:71100 )

• marginal zone B cell numbers are found at 5?25% of wild-type controls

abnormal B cell activation ( J:71100 )

• production of antibodies to T cell dependent antigens is impaired

• B cells activated in vitro exhibit a stronger calcium response with a delayed maximum in comparison to wild-type controls

decreased IgG1 level ( J:71100 )

• IgG1 levels are reduced in the serum by almost 10-fold

• when immunized with T cell dependent antigen, production of antigen-specific IgG1 is consistently lower than controls

hematopoietic system

decreased mature B cell number ( J:71100 )

• there is about a 30% reduction in the number of recirculating B cells found in the bone marrow

decreased B-1 B cell number ( J:71100 )

• B-1 B cells numbers are reduced by 10-fold in the peritoneum

decreased marginal zone B cell number ( J:71100 )

• marginal zone B cell numbers are found at 5?25% of wild-type controls

abnormal B cell activation ( J:71100 )

• production of antibodies to T cell dependent antigens is impaired

• B cells activated in vitro exhibit a stronger calcium response with a delayed maximum in comparison to wild-type controls

decreased IgG1 level ( J:71100 )

• IgG1 levels are reduced in the serum by almost 10-fold

• when immunized with T cell dependent antigen, production of antigen-specific IgG1 is consistently lower than controls

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79b^tm1Gzmn mutation (1 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:179254 )

• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

absent pre-B cells ( J:179254 )

hematopoietic system

abnormal B cell differentiation ( J:179254 )

• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

absent pre-B cells ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

hematopoietic system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a⁺ Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

hematopoietic system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79b^tm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested B cell differentiation ( J:71100 )

• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1⁺HSA^bright step

absent mature B cells ( J:71100 )

• B cells are absent from the periphery

hematopoietic system

arrested B cell differentiation ( J:71100 )

• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1⁺HSA^bright step

absent mature B cells ( J:71100 )

• B cells are absent from the periphery

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm3Mnz/Cd79b^tm3Mnz
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79b^tm3Mnz mutation (1 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:128768 )

N	• unlike in Cd79b^tm3Mnz homozygotes, B cells proliferate in response to BCR cross-linking

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:124400 )

• B cells fail to develop beyond the pro-B cell stage

hematopoietic system

abnormal B cell differentiation ( J:124400 )

• B cells fail to develop beyond the pro-B cell stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24