Phenotypes associated with this allele

• Allele Symbol: Adora1^tm1Jgsc
• Allele Name: targeted mutation 1, Jurgen Schnermann
• Allele ID: MGI:2388340
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora1^tm1Jgsc/Adora1^tm1Jgsc	involves: 129S1/Sv * 129X1/SvJ	MGI:3055093
hm2	Adora1^tm1Jgsc/Adora1^tm1Jgsc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4358186
hm3	Adora1^tm1Jgsc/Adora1^tm1Jgsc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5296236

Genotype
MGI:3055093

hm1

• Allelic Composition: Adora1^tm1Jgsc/Adora1^tm1Jgsc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:92598 )

• no bradycardia is induced by treatment with 5'-AMP, unlike in wild-type mice

Genotype
MGI:4358186

hm2

• Allelic Composition: Adora1^tm1Jgsc/Adora1^tm1Jgsc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

homeostasis/metabolism

increased circulating creatinine level ( J:127544 )

• following reperfusion 15 minutes or 24 hours after renal ischemia induced by CCPA (2-chloro-N6-cyclopentyl-adenosine), mice fail to exhibit a reduction in serum creatinine levels unlike in similarly treated wild-type mice

increased susceptibility to kidney reperfusion injury ( J:127544 )

• following reperfusion 15 minutes or 24 hours after renal ischemia induced by CCPA (2-chloro-N6-cyclopentyl-adenosine), mice fail to exhibit a reduction in serum creatinine levels unlike in similarly treated wild-type mice

• following reperfusion after renal ischemia induced by CCPA, mice exhibit increased neutrophil infiltration into the kidney compared with similarly treated wild-type mice

renal/urinary system

increased susceptibility to kidney reperfusion injury ( J:127544 )

• following reperfusion 15 minutes or 24 hours after renal ischemia induced by CCPA (2-chloro-N6-cyclopentyl-adenosine), mice fail to exhibit a reduction in serum creatinine levels unlike in similarly treated wild-type mice

• following reperfusion after renal ischemia induced by CCPA, mice exhibit increased neutrophil infiltration into the kidney compared with similarly treated wild-type mice

Genotype
MGI:5296236

hm3

• Allelic Composition: Adora1^tm1Jgsc/Adora1^tm1Jgsc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

renal/urinary system

renal/urinary system phenotype ( J:71091 )

N • homozygotes are viable, fertile and overtly normal with no apparent defects in renal histology

N • no significant changes in mean glomerular filtration rate (GFR) are noted during a 45-min observation period relative to wild-type controls

absent tubuloglomerular feedback response ( J:71091 )

• unlike in wild-type mice, TGF responses to an increase in loop of Henle flow rate from 0 to 30 nl/min, either determined as change of stop flow pressure or early proximal flow rate, are completely absent indicating that vasoconstriction resulting from an increase in macula densa NaCl concentration is abolished

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:71091 )

N • homozygotes have normal plasma Na, K, Cl, creatinine, urea, and glucose concentrations relative to wild-type and heterozygous controls

N • homozygotes show normal urine concentrations of Na, K and Cl as well as normal urine osmolarity and urine flow relative to wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:71091 )

N • homozygotes display normal systolic arterial blood pressure and heart rates relative to wild-type controls