Phenotypes associated with this allele

• Allele Symbol: Slc9a3^tm1Ges
• Allele Name: targeted mutation 1, Gary E Shull
• Allele ID: MGI:2388341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc9a3^tm1Ges/Slc9a3^tm1Ges	Not Specified	MGI:3032962

Genotype
MGI:3032962

hm1

• Allelic Composition: Slc9a3^tm1Ges/Slc9a3^tm1Ges
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypotension ( J:70885 )

digestive/alimentary system

esophageal epithelium hyperplasia ( J:70885 )

abnormal intestine morphology ( J:70885 )

• all segments of the intestinal tract were enlarged

distended cecum ( J:70885 )

megacolon ( J:70885 )

abnormal digestive system physiology ( J:70885 )

• pH of the luminal contents was increased in all intestinal sections

diarrhea ( J:70885 )

homeostasis/metabolism

abnormal blood pH regulation ( J:70885 )

• small, but significant, decreases in pH and hydrocarbonate (HCO₃-)

increased circulating aldosterone level ( J:70885 )

• plasma levels were increased five-fold relative to controls

abnormal renal water reabsorption ( J:70885 )

• fluid absorption by proximal renal tubules was reduced by 69%

renal tubular acidosis ( J:70885 )

• decreases in pH and HCO₃- were consistent with mild proximal tubular acidosis

renal/urinary system

renal tubular acidosis ( J:70885 )

• decreases in pH and HCO₃- were consistent with mild proximal tubular acidosis

abnormal renal reabsorption ( J:70885 )

• HCO₃- absorption by proximal renal tubules was reduced by 61%

abnormal renal water reabsorption ( J:70885 )

• fluid absorption by proximal renal tubules was reduced by 69%

endocrine/exocrine glands

dilated rete testis ( J:125658 )

♂ • rete testis dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice

reproductive system

dilated rete testis ( J:125658 )

♂ • rete testis dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice

dilated efferent ductule of testis ( J:125658 )

♂ • ductules dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice

male infertility ( J:125658 )

♂ • males are sterile