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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eportm1Jni
targeted mutation 1, James N Ihle
MGI:2388345
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eportm1Jni/Eportm1Jni involves: 129S1/Sv * C57BL/6 MGI:3706819


Genotype
MGI:3706819
hm1
Allelic
Composition		 Eportm1Jni/Eportm1Jni
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1Jni mutation (0 available); any Epor mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythropoiesis ( J:70036 )
• the numbers of erythroid burst-forming-units (BFU-E) are slightly reduced in fetal liver cell preparations relative to wild-type
• in adult bone marrow, the numbers of eryhtroid colony-forming-units (CFU-E) are increased 2-fold relative to wild-type
increased hematocrit ( J:70036 )
• embryos at E14.5, E15.5, and E18.5, and adults show slightly higher hematocrits than wild-type
• challenging mutants with continuous injections of Epo results in a greater increase in hematocrit than in wild-type or homozygous Eportm2Jni mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory