All Phenotypes Prdm2<tm1Shg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prdm2^tm1Shg
targeted mutation 1, Shi Huang
MGI:2388354

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm2^tm1Shg/Prdm2^tm1Shg	involves: 129S2/SvPas * C57BL/6	MGI:3041264
ht2	Prdm2^tm1Shg/Prdm2⁺	involves: 129S2/SvPas * C57BL/6	MGI:3041265
cx3	Prdm2^tm1Shg/Prdm2^tm1Shg Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas * C57BL/6	MGI:3041266

Allelic Composition	Prdm2^tm1Shg/Prdm2^tm1Shg
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm2^tm1Shg mutation (1 available); any Prdm2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71406 )

• obvious decline in survival between 450 and 600 days of age, whereas wild-type controls had no such decline

neoplasm

increased tumor incidence ( J:71406 )

• at 20 months of age 80% of mice examined had tumors, incidence in wild-type controls was 30%

• at 20 months of age incidence of tumors in multiple organs was 37% vs. 4% in wild-type controls

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 3% of mice examined vs. 0% in wild-type controls

increased lymphoma incidence ( J:71406 )

• at 20 months, 3% of mice examined had fibrosing large cell lymphoma vs. 0% in wild-type controls

increased B cell derived lymphoma incidence ( J:71406 )

• at 20 months of age 37% of mice examined had diffuse large B-cell lymphoma vs. 0% in wild-type controls

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 37% of mice examined vs. 17% in wild-type controls

increased hemangiosarcoma incidence ( J:71406 )

• at 20 months, 5% of mice examined had hemangiosarcoma vs. 0% in wild-type controls

respiratory system

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 37% of mice examined vs. 17% in wild-type controls

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 3% of mice examined vs. 0% in wild-type controls

nervous system

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 3% of mice examined vs. 0% in wild-type controls

Allelic Composition	Prdm2^tm1Shg/Prdm2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm2^tm1Shg mutation (1 available); any Prdm2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71406 )

• obvious decline in survival between 450 and 600 days of age, whereas wild-type controls had no such decline

neoplasm

increased tumor incidence ( J:71406 )

• at 20 months of age 49% of mice examined had tumors, incidence in wild-type controls was 30%

• incidence of tumors in multiple organs was 19% vs. 4% in wild-type controls

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

increased lymphoma incidence ( J:71406 )

• at 20 months, 2% of mice examined had fibrosing large cell lymphoma vs. 0% in wild-type controls

increased B cell derived lymphoma incidence ( J:71406 )

• at 20 months of age 19% of mice examined had diffuse large B-cell lymphoma vs. 0% in wild-type controls

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 21% of mice examined vs. 17% in wild-type controls

increased hemangiosarcoma incidence ( J:71406 )

• at 20 months, 2% of mice examined had hemangiosarcoma vs. 0% in wild-type controls

nervous system

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

respiratory system

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 21% of mice examined vs. 17% in wild-type controls

Allelic Composition	Prdm2^tm1Shg/Prdm2^tm1Shg Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm2^tm1Shg mutation (1 available); any Prdm2 mutation (99 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71406 )

• mean age of survival was 415 days vs. mice heterozygous for Trp53^tm1Tyj alone or homozygous Prdm2^tm1Shg alone, which survived to ~550 days

neoplasm

increased tumor incidence ( J:71406 )

• of types similar to those found in mice homozygous for Prdm2^tm1Shg alone

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