Phenotypes associated with this allele

• Allele Symbol: Cbfb^tm1Ppl
• Allele Name: targeted mutation 1, Pu P Liu
• Allele ID: MGI:2388355
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cbfb^tm1Ppl/Cbfb^+	either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)	MGI:3838168

Genotype
MGI:3838168

ht1

• Allelic Composition: Cbfb^tm1Ppl/Cbfb⁺
• Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:36594 )

• all embryos normal at E11.5

• lethality between E11.5 and E13.5

cardiovascular system

internal hemorrhage ( J:36594 )

• multiple hemorrhages begin to develop at E12

hemopericardium ( J:36594 )

• sometimes

hemoperitoneum ( J:36594 )

• sometimes

intracranial hemorrhage ( J:36594 )

• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos

• periventricular regions of the striatum, pons, medulla

• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII

brainstem hemorrhage ( J:36594 )

intraventricular hemorrhage ( J:36594 )

• blood often accumulates in the ventricles

spinal hemorrhage ( J:36594 )

cellular

increased apoptosis ( J:36594 )

• observed in areas susceptible to hemorrhage

liver/biliary system

small liver ( J:36594 )

• from E11.5 to E13.5

pale liver ( J:36594 )

• few or no erythropoietic cells

• no megakaryocytes

hematopoietic system

extramedullary hematopoiesis ( J:36594 )

• no definitive hematopoietic cells in the hepatic cords at E11.5-E13.5

• mostly immature yolk sac derived erythrocytes in the circulation at E12.5, about 78%

impaired hematopoiesis ( J:36594 )

• reduced ability of fetal liver and yolk cells to proliferate and differentiate in vitro

nervous system

intracranial hemorrhage ( J:36594 )

• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos

• periventricular regions of the striatum, pons, medulla

• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII

brainstem hemorrhage ( J:36594 )

intraventricular hemorrhage ( J:36594 )

• blood often accumulates in the ventricles

spinal hemorrhage ( J:36594 )

homeostasis/metabolism

hemopericardium ( J:36594 )

• sometimes