Phenotypes associated with this allele

• Allele Symbol: Folh1^tm1Nle
• Allele Name: targeted mutation 1, Joseph H Neale
• Allele ID: MGI:2388359
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Folh1^tm1Nle/Folh1^tm1Nle	involves: 129X1/SvJ * C57BL/6J	MGI:3640319

Genotype
MGI:3640319

hm1

• Allelic Composition: Folh1^tm1Nle/Folh1^tm1Nle
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:79368 )

N • normal horizontal, vertical, and grooming behavior observed in open field tests

N • balance is normal in rotarod testing

increased food intake ( J:103536 )

• 26% increase in food intake

increased anxiety-related response ( J:103536 )

• fewer entries into the closed arms of an elevated + maze

nervous system

decreased susceptibility to ischemic brain injury ( J:103536 )

• after experimental middle cerebral artery occlusion

decreased cerebral infarct size ( J:103536 )

• 36% reduction in infarct volume

abnormal sciatic nerve morphology ( J:103536 )

• axon area of the sciatic nerve is significantly reduced

• myelin area is also significantly reduced

abnormal peripheral nervous system regeneration ( J:103536 )

• less susceptibility to sciatic nerve crush injury

• recovery is faster and more and larger fibers are present after nerve crush than in controls

cardiovascular system

abnormal vascular endothelial cell morphology ( J:110318 )

• Folh-deficient endothelial cells show an increase in membrane protrusions in multiple directions and an apparent loss of normal structural integrity

abnormal angiogenesis ( J:110318 )

• invasion of endothelial cells during angiogenesis is severely impaired in null mice; Folh-deficient endothelial cells cannot penetrate Matrigel in vitro

decreased angiogenesis ( J:110318 )

• in null mice injected with Matrigel, there is a striking attenuation of neovessel formation in the Matrigel plug

increased systemic arterial blood pressure ( J:103536 )

• higher basal mean arterial pressure

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:103536 )

• after experimental middle cerebral artery occlusion

decreased cerebral infarct size ( J:103536 )

• 36% reduction in infarct volume