Analysis Tools
adipose tissue
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• by 10 weeks on a high fat diet, homozygous males had 75% less body fat and females had 50% less body fat than wild-type
• on a low fat diet, homozygous females but not males had less body fat at 12 weeks of age however at 28 weeks of age, males also had less body fat than wild-type mice
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behavior/neurological
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• homozygous males, but not females, consumed less food on a high fat diet than wild-type
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growth/size/body
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• homozygous males but not females had a lower mean lean body mass at the end of 14 weeks on a high fat diet
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• homozygotes gained significantly less weight than wild-type on a high fat diet at 14 weeks on the diet, with males gaining less weight than females
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homeostasis/metabolism
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• following a high fat diet, fasting insulin levels were lower in homozygous males, but not females, compared to wild-type
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• both male and female homozygotes on a high fat diet exhibited increased energy expenditure compared to wild-type during both light and dark cycles, however females expended more energy than males
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• homozygotes gained significantly less weight than wild-type on a high fat diet at 14 weeks on the diet, with males gaining less weight than females
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• both male and female homozygotes on a high fat diet had improved glucose clearance after glucose challenge compared to wild-type
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