All Phenotypes Sag<tm1Jnc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sag^tm1Jnc
targeted mutation 1, Jeannie Chen
MGI:2388373

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sag^tm1Jnc/Sag^tm1Jnc	involves: 129S/SvEv	MGI:2671969
cx2	Sag^tm1Jnc/Sag^tm1Jnc Rho^tm1Shda/Rho^tm1Shda	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3710687
cx3	Arr3^tm1Chcr/Arr3^tm1Chcr Sag^tm1Jnc/Sag^tm1Jnc	involves: 129S/SvEv * C57BL/6	MGI:3810255

Allelic Composition	Sag^tm1Jnc/Sag^tm1Jnc
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sag^tm1Jnc mutation (9 available); any Sag mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:139694 )

N	• mice exhibit normal cone electrophysiology

abnormal retina rod cell outer segment morphology ( J:43294 )

• the rod outer segment is disorganized and 25% shorter than in wild-type mice

• however, raising mice in darkness reduces the effect

abnormal rod electrophysiology ( J:43294 , J:120882 )

• rods exhibit an abnormal falling phase of the flash response compared to in wild-type mice (J:43294)

• recovery from flash response is prolonged in the final phase unlike wild type mice (J:43294)

• however, response to light adaptation is normal (J:43294)

• slow phase of the dim-flash response is 10-fold longer than in the Arrb1^tm1Jnc Rho^tm1Shda double homozygotes (J:120882)

• prolonged decay of slow-phase response is associated with increased meta-II decay (J:120882)

nervous system

abnormal retina rod cell outer segment morphology ( J:43294 )

• the rod outer segment is disorganized and 25% shorter than in wild-type mice

• however, raising mice in darkness reduces the effect

Allelic Composition	Sag^tm1Jnc/Sag^tm1Jnc Rho^tm1Shda/Rho^tm1Shda
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rho^tm1Shda mutation (0 available); any Rho mutation (51 available)
Sag^tm1Jnc mutation (9 available); any Sag mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal rod electrophysiology ( J:120882 )

• accelerated meta-II decay

Allelic Composition	Arr3^tm1Chcr/Arr3^tm1Chcr Sag^tm1Jnc/Sag^tm1Jnc
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arr3^tm1Chcr mutation (0 available); any Arr3 mutation (11 available)
Sag^tm1Jnc mutation (9 available); any Sag mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cone electrophysiology ( J:139694 )

• cones exhibit a greatly slowed recovery from strong flashes compared to wild-type cones

• the amplitude of slow tails of recovery are increased compared to in wild-type mice

• S- and M-cone opsin driven dim-flash responses exhibit slow tail in recovery unlike wild-type mice

• however, the peak time of dim-flash response is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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