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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rdh5tm1Drie
targeted mutation 1, Carola A G G Driessen
MGI:2388375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rdh5tm1Drie/Rdh5tm1Drie Not Specified MGI:3578360
cx2
 		Rdh11tm1Tsyk/Rdh11tm1Tsyk
Rdh5tm1Drie/Rdh5tm1Drie 		involves: 129S1/Sv * 129X1/SvJ MGI:3578359


Genotype
MGI:3578360
hm1
Allelic
Composition		 Rdh5tm1Drie/Rdh5tm1Drie
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh5tm1Drie mutation (0 available); any Rdh5 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
delayed dark adaptation ( J:97788 )
• slightly delayed dark adaptation and decreased 11-cis-retinal levels following exposure to intense bleaching conditions (500 cd/m2 for 3 minutes)
• not as delayed as the mice lacking both Rdh11 and Rdh5 but more severe than mice homozygous for Rdh11tm1Kpal alone




Genotype
MGI:3578359
cx2
Allelic
Composition		 Rdh11tm1Tsyk/Rdh11tm1Tsyk
Rdh5tm1Drie/Rdh5tm1Drie
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh11tm1Tsyk mutation (0 available); any Rdh11 mutation (18 available)
Rdh5tm1Drie mutation (0 available); any Rdh5 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye electrophysiology ( J:97788 )
• slightly reduced a- and b-wave amplitude responses are seen under dark adapted conditions
delayed dark adaptation ( J:97788 )
• delayed dark adaptation and decreased 11-cis-retinal levels following exposure to intense bleaching conditions (500 cd/m2 for 3 minutes)
• more severely delayed than in either single homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory