Analysis Tools
mortality/aging
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• 7 of 10 mice die at birth with uninflated lungs and the remaining die within hours of respiratory insufficiency
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cardiovascular system
| N |
• unlike in other splotched mutants, mice exhibit normal outflow tract development
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• dilated at E16.5
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• the caval veins are overextended
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• mice that live a few hours beyond birth exhibit a large opening in the right tricuspid valve
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• mice exhibit either thickened or thinned interventricular septum
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• VSDs occur in the wall overlying the muscular part of the septum, some of which were present at the position where the
septum attaches to the interventricular groove
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• at E16.5, the ventricular septum is thickened compared to in wild-type mice
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• in mice that live a few hours beyond birth
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• despite normal outflow tract, mice exhibit congestive heart failure indicated by a blood engorged liver
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muscle
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• mice exhibit abnormal diaphragm and tongue musculature
• however, limb musculature develops normally
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• around the time of birth, tongue musculature is underdeveloped and disorganized
• around the time of birth, lateral tongue muscle exhibits a decrease in diameter compared to wild-type musculature
• however, tongue musculature is normal at E13.5
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• at E16.5, the muscles of the diaphragm is underdeveloped with fibers being both shorter and thinner than in wild-type mice and possessing gaps in the musculature
• however, diaphragm musculature is normal at E13.5
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nervous system
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• caudal neural tube outgrowths are present in 10% of mice
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spina bifida
(
J:79365
)
|
• in 10% of mice
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exencephaly
(
J:79365
)
|
• in 10% of mice
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respiratory system
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• 7 of 10 mice exhibit compact alveoli indicating a failure to inflate
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• in mice that live a few hours beyond birth
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homeostasis/metabolism
hematopoietic system
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• the right and left lobes exhibit an abnormal, more caudal location
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• mutant thymus has an abnormal, more caudal location
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neoplasm
| N |
• unlike in t(2;13) translocations that place FOXO1A under the control of the PAX3 promoter in humans, mice exhibit no signs of tumorigenesis
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immune system
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• the right and left lobes exhibit an abnormal, more caudal location
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• mutant thymus has an abnormal, more caudal location
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embryo
|
• caudal neural tube outgrowths are present in 10% of mice
|
spina bifida
(
J:79365
)
|
• in 10% of mice
|
craniofacial
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• around the time of birth, tongue musculature is underdeveloped and disorganized
• around the time of birth, lateral tongue muscle exhibits a decrease in diameter compared to wild-type musculature
• however, tongue musculature is normal at E13.5
|
digestive/alimentary system
|
• around the time of birth, tongue musculature is underdeveloped and disorganized
• around the time of birth, lateral tongue muscle exhibits a decrease in diameter compared to wild-type musculature
• however, tongue musculature is normal at E13.5
|
endocrine/exocrine glands
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• the right and left lobes exhibit an abnormal, more caudal location
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• mutant thymus has an abnormal, more caudal location
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growth/size/body
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• around the time of birth, tongue musculature is underdeveloped and disorganized
• around the time of birth, lateral tongue muscle exhibits a decrease in diameter compared to wild-type musculature
• however, tongue musculature is normal at E13.5
|
