renal/urinary system
• at E10.75, mice exhibit impaired condensation of kidney mesenchyme compared with wild-type mice
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Allele Symbol Allele Name Allele ID |
Sall1tm1Ryn targeted mutation 1, Ryuichi Nishinakamura MGI:2388379 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• at E10.75, mice exhibit impaired condensation of kidney mesenchyme compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• all die within 24 hours after birth
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• metanephric mesenchyme shows increased apoptosis at E11.5
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• remnant kidneys have multiple cysts
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• remnant kidneys show a disorganized cortical structure
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• metanephric mesenchyme forms, however it is reduced in size and is not invaded by the ureteric bud
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• metanephric mesenchyme shows increased apoptosis at E11.5
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• 39.3% have two small remnant kidneys
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• remnant kidneys show shrunken glomeruli
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• remnant kidneys show necrotic proximal tubules
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• remnant kidneys show necrotic proximal tubules
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• 32.1% have no kidneys or ureters
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• 28.6% exhibit unilateral kidney agenesis and hypoplasia on the other side
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• 32.1% have no kidneys or ureters
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• E11.5 kidney rudiments cultured in vitro form no or only small numbers of branched structures compared to the development of a fully branched kidney structure in controls
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• the ureteric bud forms but fails to invade the metanephric mesenchyme
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• the layer structure of olfactory bulbs in newborns is slightly disorganized
• however, do not exhibit any other ear abnormalities
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• do not suckle
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N |
• no limb deformities
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• metanephric mesenchyme shows increased apoptosis at E11.5
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• remnant kidneys have multiple cysts
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• all die perinatally
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• severity or kidney abnormalities is comparable to that seen in single Sall1 homozygotes
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• the remnant kidneys have multiple cysts
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• exhibit reduced kidney size at E12.5
• 41.7% have two small remnant kidneys
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• 25% have no kidneys or ureters bilaterally
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• 33.3% have unilateral kidney agenesis and hypoplasia on the other side
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• 25% have no kidneys or ureters bilaterally
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• exhibit impaired ureteric branching at E12.5
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• the remnant kidneys have multiple cysts
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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