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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sall1tm1Ryn
targeted mutation 1, Ryuichi Nishinakamura
MGI:2388379
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sall1tm1Ryn/Sall1tm1Ryn involves: 129S/SvEv MGI:4459957
hm2
Sall1tm1Ryn/Sall1tm1Ryn involves: 129S/SvEv * C57BL/6N MGI:3699215
cx3
Sall1tm1Ryn/Sall1tm1Ryn
Sall2tm1Ryn/Sall2tm1Ryn
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3699226


Genotype
MGI:4459957
hm1
Allelic
Composition
Sall1tm1Ryn/Sall1tm1Ryn
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Ryn mutation (2 available); any Sall1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• at E10.75, mice exhibit impaired condensation of kidney mesenchyme compared with wild-type mice




Genotype
MGI:3699215
hm2
Allelic
Composition
Sall1tm1Ryn/Sall1tm1Ryn
Genetic
Background
involves: 129S/SvEv * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Ryn mutation (2 available); any Sall1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die within 24 hours after birth

embryo
• metanephric mesenchyme shows increased apoptosis at E11.5

renal/urinary system
• remnant kidneys have multiple cysts
• remnant kidneys show a disorganized cortical structure
• metanephric mesenchyme forms, however it is reduced in size and is not invaded by the ureteric bud
• metanephric mesenchyme shows increased apoptosis at E11.5
• 39.3% have two small remnant kidneys
• remnant kidneys show shrunken glomeruli
• remnant kidneys show necrotic proximal tubules
• remnant kidneys show necrotic proximal tubules
• 32.1% have no kidneys or ureters
• 28.6% exhibit unilateral kidney agenesis and hypoplasia on the other side
• 32.1% have no kidneys or ureters
• E11.5 kidney rudiments cultured in vitro form no or only small numbers of branched structures compared to the development of a fully branched kidney structure in controls
• the ureteric bud forms but fails to invade the metanephric mesenchyme

nervous system
• the layer structure of olfactory bulbs in newborns is slightly disorganized
• however, do not exhibit any other ear abnormalities

behavior/neurological
• do not suckle

limbs/digits/tail
N
• no limb deformities

cellular
• metanephric mesenchyme shows increased apoptosis at E11.5

growth/size/body
• remnant kidneys have multiple cysts




Genotype
MGI:3699226
cx3
Allelic
Composition
Sall1tm1Ryn/Sall1tm1Ryn
Sall2tm1Ryn/Sall2tm1Ryn
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Ryn mutation (2 available); any Sall1 mutation (78 available)
Sall2tm1Ryn mutation (1 available); any Sall2 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• severity or kidney abnormalities is comparable to that seen in single Sall1 homozygotes
• the remnant kidneys have multiple cysts
• exhibit reduced kidney size at E12.5
• 41.7% have two small remnant kidneys
• 25% have no kidneys or ureters bilaterally
• 33.3% have unilateral kidney agenesis and hypoplasia on the other side
• 25% have no kidneys or ureters bilaterally
• exhibit impaired ureteric branching at E12.5

growth/size/body
• the remnant kidneys have multiple cysts





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory