All Phenotypes Sall1<tm2Ryn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sall1^tm2Ryn
targeted mutation 2, Ryuichi Nishinakamura
MGI:2388380

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall1^tm2Ryn/Sall1^tm2Ryn	involves: 129P2/OlaHsd * C57BL/6N	MGI:3699219
ht2	Sall1^tm2Ryn/Sall1⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:3699218
cx3	Sall1^tm2Ryn/Sall1⁺ Sall4^tm2Ryn/Sall4⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699211

Allelic Composition	Sall1^tm2Ryn/Sall1^tm2Ryn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm2Ryn mutation (0 available); any Sall1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:71242 )

• exhibit phenotypes identical to those of Sall1^tm1Ryn homozygotes, although no data is presented in J:71242

embryo

increased metanephric mesenchyme apoptosis ( J:71242 )

renal/urinary system

kidney cyst ( J:71242 )

abnormal kidney cortex morphology ( J:71242 )

abnormal metanephric mesenchyme morphology ( J:71242 )

increased metanephric mesenchyme apoptosis ( J:71242 )

small kidney ( J:71242 )

renal glomerulus atrophy ( J:71242 )

abnormal proximal convoluted tubule morphology ( J:71242 )

renal tubular necrosis ( J:71242 )

absent kidney ( J:71242 )

single kidney ( J:71242 )

absent ureter ( J:71242 )

impaired branching involved in ureteric bud morphogenesis ( J:71242 )

abnormal ureteric bud invasion ( J:71242 )

nervous system

abnormal olfactory bulb morphology ( J:71242 )

behavior/neurological

abnormal suckling behavior ( J:71242 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:71242 )

N	• no limb deformities

cellular

increased metanephric mesenchyme apoptosis ( J:71242 )

growth/size/body

kidney cyst ( J:71242 )

Allelic Composition	Sall1^tm2Ryn/Sall1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm2Ryn mutation (0 available); any Sall1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:71242 )

• many die in the perinatal period without any apparent histological abnormalities

Allelic Composition	Sall1^tm2Ryn/Sall1⁺ Sall4^tm2Ryn/Sall4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm2Ryn mutation (0 available); any Sall1 mutation (78 available)
Sall4^tm2Ryn mutation (0 available); any Sall4 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:118119 )

• none survive after birth

renal/urinary system

absent kidney ( J:118119 )

• 6 of 38 exhibit bilateral renal agenesis

single kidney ( J:118119 )

• 10 of 38 exhibit unilateral renal agenesis

cardiovascular system

ventricular septal defect ( J:118119 )

• 70% of E17.5-18.5 mutants exhibit ventricular septum defects

digestive/alimentary system

abnormal anus morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

anal stenosis ( J:118119 )

• exhibit anal stenosis at E17.5

abnormal rectum morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

nervous system

exencephaly ( J:118119 )

• seen in 44.7% of E13.5-P0 mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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