Phenotypes associated with this allele

• Allele Symbol: Gjd2^tm1Paul
• Allele Name: targeted mutation 1, David L Paul
• Allele ID: MGI:2388383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjd2^tm1Paul/Gjd2^tm1Paul	involves: 129S4/SvJae * C57BL/6	MGI:3810172

Genotype
MGI:3810172

hm1

• Allelic Composition: Gjd2^tm1Paul/Gjd2^tm1Paul
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:71117 )

N • incidence, strength and short-term plasticity of inhibitory postsynaptic potentials are normal

abnormal CNS synaptic transmission ( J:71117 )

• mice exhibit rare and weak electrical coupling compared to in wild-type mice

• the average coupling of three coupled pairs of fast spiking interneurons is 10% of wild-type

• electrical synapses of long threshold spiking cells are absent unlike in wild-type miceelectrical synapses of long threshold spiking cells are absent unlike in wild-type mice

• correlated inhibition during ACPD-induced spiking in long threshold spiking cells is inhibited compared to in wild-type mice