Phenotypes associated with this allele

• Allele Symbol: Klk8^tm1Lth
• Allele Name: targeted mutation 1, Richard Lathe
• Allele ID: MGI:2388384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klk8^tm1Lth/Klk8^tm1Lth	involves: 129P2/OlaHsd * C57BL/6	MGI:3834160

Genotype
MGI:3834160

hm1

• Allelic Composition: Klk8^tm1Lth/Klk8^tm1Lth
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:71533 )

• following treatment with 30 mg/kg kainic acid most mice die while most treatment matched controls survive

nervous system

nervous system phenotype ( J:71533 )

N • despites expression patterns and suggested function of the endogenous gene, no abnormalities are detected in hippocampal morphology or long term potentiation

N • unlike EPSPs, the input output relationships for fEPSPs are similar to controls

increased susceptibility to pharmacologically induced seizures ( J:71533 )

• following treatment with 30 mg/kg kainic acid most mice develop an additional extreme tonic-clonic phase not seen in wild-type controls

• however, latency of seizures and early phase signs are similar to wild-type controls

abnormal excitatory postsynaptic potential ( J:71533 )

• the extent of polyspiking is increased in the period of afferent stimulation in an assay involving repetitive stimulation (30 shocks at 1Hz) of the Schaffer collateral commissural pathway

behavior/neurological

behavior/neurological phenotype ( J:71533 )

N • no defects are detected in spatial reference memory

increased susceptibility to pharmacologically induced seizures ( J:71533 )

• following treatment with 30 mg/kg kainic acid most mice develop an additional extreme tonic-clonic phase not seen in wild-type controls

• however, latency of seizures and early phase signs are similar to wild-type controls

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:71533 )

• following treatment with 30 mg/kg kainic acid most mice die while most treatment matched controls survive