About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Drd2tm1Schm
targeted mutation 1, Claudia Schmauss
MGI:2388386
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Drd2tm1Schm/Drd2tm1Schm B6.Cg-Drd2tm1Schm MGI:3623139
hm2
 		Drd2tm1Schm/Drd2tm1Schm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623123
cx3
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm 		B6.Cg-Drd2tm1Schm Drd3tm1Schm MGI:3623140
cx4
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623125
cx5
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623127
cx6
 		Drd2tm1Schm/Drd2+
Drd3tm1Schm/Drd3tm1Schm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623128


Genotype
MGI:3623139
hm1
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Genetic
Background		 B6.Cg-Drd2tm1Schm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:106280 )
• mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological
increased fluid intake ( J:106280 )
• nulls drink more water than wild-type
increased food intake ( J:106280 )
• nulls eat significantly more than wild-type

digestive/alimentary system
increased defecation amount ( J:106280 )
• stool frequency in mutants is significantly greater than in wild-type
abnormal intestinal absorption ( J:106280 )
• fast rate of GI transit prevents complete digestion or absorption of food
abnormal intestinal transit time ( J:106280 )
• mean transit time through the bowel is significantly faster in homozygotes compared to wild-type
abnormal large intestinal transit time ( J:106280 )
• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in homozygotes compared to wild-type




Genotype
MGI:3623123
hm2
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:79483 )
• mortality between P30 and 45 is 20%

growth/size/body
decreased body size ( J:79483 )
• between P15 and 45 are smaller than wild-type littermates
decreased body weight ( J:79483 )
• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes
bradykinesia ( J:79483 )
• adult homozygotes display bradykinesia; this only becomes apparent after P15 and is most severe between P15 and 45

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623140
cx3
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 B6.Cg-Drd2tm1Schm Drd3tm1Schm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:106280 )
• double mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological
increased fluid intake ( J:106280 )
• double nulls drink more water than wild-type
increased food intake ( J:106280 )
• double nulls eat significantly more than wild-type

digestive/alimentary system
increased defecation amount ( J:106280 )
• stool frequency in double mutants is significantly greater than in wild-type
abnormal intestinal absorption ( J:106280 )
• fast rate of GI transit prevents complete digestion or absorption of food
abnormal intestinal transit time ( J:106280 )
• mean transit time through the bowel is significantly faster in double homozygotes compared to wild-type but does not differ significantly from D2 nulls
abnormal large intestinal transit time ( J:106280 )
• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in double homozygotes compared to wild-type but does not differ significantly from D2 nulls




Genotype
MGI:3623125
cx4
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:79483 )
• mortality is around 30%, occurring between 4 and 15 days of age

growth/size/body
decreased body weight ( J:79483 )
• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological
abnormal locomotor behavior ( J:79483 )
• adult male double mutants 70 days of age show lower activity than D2 single mutants with lower photobeam interruptions and lower total distance traveled

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623127
cx5
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623128
cx6
Allelic
Composition		 Drd2tm1Schm/Drd2+
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory