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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Drd2tm1Schm
targeted mutation 1, Claudia Schmauss
MGI:2388386
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Drd2tm1Schm/Drd2tm1Schm B6.Cg-Drd2tm1Schm MGI:3623139
hm2
 		Drd2tm1Schm/Drd2tm1Schm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623123
cx3
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm 		B6.Cg-Drd2tm1Schm Drd3tm1Schm MGI:3623140
cx4
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623125
cx5
 		Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623127
cx6
 		Drd2tm1Schm/Drd2+
Drd3tm1Schm/Drd3tm1Schm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623128


Genotype
MGI:3623139
hm1
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Genetic
Background		 B6.Cg-Drd2tm1Schm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:106280 )
• mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological
increased fluid intake ( J:106280 )
• nulls drink more water than wild-type
increased food intake ( J:106280 )
• nulls eat significantly more than wild-type

digestive/alimentary system
increased defecation amount ( J:106280 )
• stool frequency in mutants is significantly greater than in wild-type
abnormal intestinal absorption ( J:106280 )
• fast rate of GI transit prevents complete digestion or absorption of food
abnormal intestinal transit time ( J:106280 )
• mean transit time through the bowel is significantly faster in homozygotes compared to wild-type
abnormal large intestinal transit time ( J:106280 )
• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in homozygotes compared to wild-type




Genotype
MGI:3623123
hm2
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:79483 )
• mortality between P30 and 45 is 20%

growth/size/body
decreased body size ( J:79483 )
• between P15 and 45 are smaller than wild-type littermates
decreased body weight ( J:79483 )
• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes
bradykinesia ( J:79483 )
• adult homozygotes display bradykinesia; this only becomes apparent after P15 and is most severe between P15 and 45

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623140
cx3
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 B6.Cg-Drd2tm1Schm Drd3tm1Schm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:106280 )
• double mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological
increased fluid intake ( J:106280 )
• double nulls drink more water than wild-type
increased food intake ( J:106280 )
• double nulls eat significantly more than wild-type

digestive/alimentary system
increased defecation amount ( J:106280 )
• stool frequency in double mutants is significantly greater than in wild-type
abnormal intestinal absorption ( J:106280 )
• fast rate of GI transit prevents complete digestion or absorption of food
abnormal intestinal transit time ( J:106280 )
• mean transit time through the bowel is significantly faster in double homozygotes compared to wild-type but does not differ significantly from D2 nulls
abnormal large intestinal transit time ( J:106280 )
• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in double homozygotes compared to wild-type but does not differ significantly from D2 nulls




Genotype
MGI:3623125
cx4
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:79483 )
• mortality is around 30%, occurring between 4 and 15 days of age

growth/size/body
decreased body weight ( J:79483 )
• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological
abnormal locomotor behavior ( J:79483 )
• adult male double mutants 70 days of age show lower activity than D2 single mutants with lower photobeam interruptions and lower total distance traveled

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623127
cx5
Allelic
Composition		 Drd2tm1Schm/Drd2tm1Schm
Drd3tm1Schm/Drd3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

homeostasis/metabolism
abnormal dopamine level ( J:79483 )
• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants




Genotype
MGI:3623128
cx6
Allelic
Composition		 Drd2tm1Schm/Drd2+
Drd3tm1Schm/Drd3tm1Schm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3tm1Schm mutation (0 available); any Drd3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:79483 )
• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes




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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory