Phenotypes associated with this allele

• Allele Symbol: Drd3^tm1Schm
• Allele Name: targeted mutation 1, Claudia Schmauss
• Allele ID: MGI:2388387
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Drd2^tm1Schm/Drd2^tm1Schm Drd3^tm1Schm/Drd3^tm1Schm	B6.Cg-Drd2^tm1Schm Drd3^tm1Schm	MGI:3623140
cx2	Drd2^tm1Schm/Drd2^tm1Schm Drd3^tm1Schm/Drd3^tm1Schm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623125
cx3	Drd2^tm1Schm/Drd2^tm1Schm Drd3^tm1Schm/Drd3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623127
cx4	Drd2^tm1Schm/Drd2^+ Drd3^tm1Schm/Drd3^tm1Schm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623128

Genotype
MGI:3623140

cx1

• Allelic Composition: Drd2^tm1Schm/Drd2^tm1Schm; Drd3^tm1Schm/Drd3^tm1Schm
• Genetic Background: B6.Cg-Drd2^tm1Schm Drd3^tm1Schm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:106280 )

• double mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological

increased fluid intake ( J:106280 )

• double nulls drink more water than wild-type

increased food intake ( J:106280 )

• double nulls eat significantly more than wild-type

digestive/alimentary system

increased defecation amount ( J:106280 )

• stool frequency in double mutants is significantly greater than in wild-type

abnormal intestinal absorption ( J:106280 )

• fast rate of GI transit prevents complete digestion or absorption of food

abnormal intestinal transit time ( J:106280 )

• mean transit time through the bowel is significantly faster in double homozygotes compared to wild-type but does not differ significantly from D2 nulls

abnormal large intestinal transit time ( J:106280 )

• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in double homozygotes compared to wild-type but does not differ significantly from D2 nulls

Genotype
MGI:3623125

cx2

• Allelic Composition: Drd2^tm1Schm/Drd2^tm1Schm; Drd3^tm1Schm/Drd3^tm1Schm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:79483 )

• mortality is around 30%, occurring between 4 and 15 days of age

growth/size/body

decreased body weight ( J:79483 )

• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological

hunched posture ( J:79483 )

abnormal locomotor behavior ( J:79483 )

• adult male double mutants 70 days of age show lower activity than D2 single mutants with lower photobeam interruptions and lower total distance traveled

homeostasis/metabolism

abnormal dopamine level ( J:79483 )

• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants

Genotype
MGI:3623127

cx3

• Allelic Composition: Drd2^tm1Schm/Drd2^tm1Schm; Drd3^tm1Schm/Drd3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal locomotor behavior ( J:79483 )

• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

homeostasis/metabolism

abnormal dopamine level ( J:79483 )

• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants

Genotype
MGI:3623128

cx4

• Allelic Composition: Drd2^tm1Schm/Drd2⁺; Drd3^tm1Schm/Drd3^tm1Schm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal locomotor behavior ( J:79483 )

• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes