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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfsf10tm1Sdg
targeted mutation 1, Lisa M Sedger
MGI:2388390
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg B6.129-Tnfsf10tm1Sdg MGI:3706169
hm2
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg C.129-Tnfsf10tm1Sdg MGI:3706168
hm3
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg involves: 129 * C57BL/6 MGI:3713754


Genotype
MGI:3706169
hm1
Allelic
Composition
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
Genetic
Background
B6.129-Tnfsf10tm1Sdg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf10tm1Sdg mutation (1 available); any Tnfsf10 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• Background Sensitivity: unlike mice on a BALB/c congenic background, mice on a C57BL/6 congenic background show no difference from controls in the rate of A20 lymphoma tumor progression

immune system
N
• despite the potential contribution of genetic epistatic factors toautoimmune disease, no signs of lymphoproliferative disease are detected




Genotype
MGI:3706168
hm2
Allelic
Composition
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
Genetic
Background
C.129-Tnfsf10tm1Sdg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf10tm1Sdg mutation (1 available); any Tnfsf10 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• exposure of mice to A20 tumor cells results in increased mortality (70% of mutants survive at day 100 compared to 100 wild-type)
• at higher doses of A20 tumor cells the difference is more pronounced (30% of nulls survive at day 100 compared to 100% wild-type at a dose of 103 A20 tumor cells)
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic BALB/c background display an impaired ability to control A20 lymphoma progression compared to wild-type mice

neoplasm
• 40 days after tumor cell injection, a threefold increase in A20 tumor nodules is seen in the liver
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic BALB/c background display an impaired ability to control A20 lymphoma progression compared to wild-type mice




Genotype
MGI:3713754
hm3
Allelic
Composition
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf10tm1Sdg mutation (1 available); any Tnfsf10 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• all lymphoid tissues and cell numbers of myeloid, lymphoid, and immature erythroid cell subpopulations are similar to controls

skeleton
N
• despite the fact that this protein binds to osteoprotegrin, bone biology is normal and mice are not osteopetrotic





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory