All Phenotypes Abcc8<tm1.1Mgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Abcc8^tm1.1Mgn
targeted mutation 1.1, Mark A Magnuson
MGI:2388392

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc8^tm1.1Mgn/Abcc8^tm1.1Mgn	involves: 129X1/SvJ * C57BL/6	MGI:2446508
cx2	Abcc8^tm1.1Mgn/Abcc8^tm1.1Mgn Abcc9^em3Nich/Abcc9^em3Nich	involves: 129X1/SvJ * C57BL/6J * CBA/J	MGI:6825758

Allelic Composition	Abcc8^tm1.1Mgn/Abcc8^tm1.1Mgn
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc8^tm1.1Mgn mutation (1 available); any Abcc8 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:79352 )

• impaired glucose-stimulated insulin secretion, but normal secretion with normal diet

homeostasis/metabolism

decreased insulin secretion ( J:79352 )

• impaired glucose-stimulated insulin secretion, but normal secretion with normal diet

hypoglycemia ( J:79352 )

• developed with age, beginning at 12 - 16 weeks

impaired glucose tolerance ( J:79352 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hyperinsulinemic hypoglycemia	DOID:13317	OMIM:PS256450	J:79352

Allelic Composition	Abcc8^tm1.1Mgn/Abcc8^tm1.1Mgn Abcc9^em3Nich/Abcc9^em3Nich
Genetic Background	involves: 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc8^tm1.1Mgn mutation (1 available); any Abcc8 mutation (78 available)
Abcc9^em3Nich mutation (0 available); any Abcc9 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber currents ( J:308986 )

• no ATP-sensitive potassium [K(ATP)] current is detected in ventricular myocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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