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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc22a8tm1Ngm
targeted mutation 1, Sanjay K Nigam
MGI:2388472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc22a8tm1Ngm/Slc22a8tm1Ngm involves: 129/Sv * C57BL/6 MGI:3029987
hm2
 		Slc22a8tm1Ngm/Slc22a8tm1Ngm involves: 129S1/Sv MGI:3798166


Genotype
MGI:3029987
hm1
Allelic
Composition		 Slc22a8tm1Ngm/Slc22a8tm1Ngm
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc22a8tm1Ngm mutation (0 available); any Slc22a8 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urine organic anion level ( J:78014 )
• organic anion transport in renal slices and in choroid plexus tissue was significantly reduced, suggesting a role for this gene product in detoxification and regulation of anion content in the cerebrospinal fluid
• hepatic transport of organic anions was unaffected

homeostasis/metabolism
abnormal urine organic anion level ( J:78014 )
• organic anion transport in renal slices and in choroid plexus tissue was significantly reduced, suggesting a role for this gene product in detoxification and regulation of anion content in the cerebrospinal fluid
• hepatic transport of organic anions was unaffected




Genotype
MGI:3798166
hm2
Allelic
Composition		 Slc22a8tm1Ngm/Slc22a8tm1Ngm
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc22a8tm1Ngm mutation (0 available); any Slc22a8 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased urine uric acid level ( J:136005 )
• the level of urinary urate is decreased 30% compared to in wild-type mice

homeostasis/metabolism
decreased urine uric acid level ( J:136005 )
• the level of urinary urate is decreased 30% compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory