Phenotypes associated with this allele

• Allele Symbol: Chst10^tm1Msch
• Allele Name: targeted mutation 1, Melitta Schachner
• Allele ID: MGI:2388475
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst10^tm1Msch/Chst10^tm1Msch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2663181

Genotype
MGI:2663181

hm1

• Allelic Composition: Chst10^tm1Msch/Chst10^tm1Msch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:79015 )

• homozygotes display increased basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus

• surprisingly, the anatomy of all major brain areas and non-neural organs appears histologically normal and no significant abnormalities are noted in general development, growth, behavior, fertility or lifespan

• in addition, post-tetanic potentiation (PTP) and paired-pulse facilitation are not significantly altered

abnormal excitatory postsynaptic potential ( J:79015 )

• the mean field excitatory postsynaptic potential (fEPSP) amplitude/slope as analyzed by the stimulus strength-fEPSP slope curve is increased, indicating that less stimulus strength is required in mutant mice than in wild-type mice to evoke fEPSPs with the same magnitude, and vice versa, the same stimulus strength induces a larger response in mutant mice relative to wild-type mice

reduced long-term potentiation ( J:79015 )

• homozygotes display reduced long-term potentiation in response to theta-burst stimulation (TBS) relative to wild-type mice

• TBS-evoked fEPSP measurements indicate significantly lower levels of modulation of depolarization during LTP induction due to higher levels of depolarization after first burst of first TBS in mutant mice, while the depolarization induced by the last burst of last TBS is similar to that of wild-type mice

behavior/neurological

abnormal learning/memory/conditioning ( J:79015 )

• homozygotes display impaired long term memory in the Morris water maze test

abnormal spatial learning ( J:79015 )

• homozygotes display impaired spatial learning in the Morris water maze test when a short (5 min) inter-trial interval is used

• in addition, homozygotes fail to show selectivity for the target area when tested after a 72-hr interval, but not when tested after a 1-hr interval