All Phenotypes Il6st<tm1Ern> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il6st^tm1Ern
targeted mutation 1, Matthias Ernst
MGI:2388478

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il6st^tm1Ern/Il6st^tm1Ern	involves: 129S1/Sv	MGI:4939802
hm2	Il6st^tm1Ern/Il6st^tm1Ern	involves: 129S1/Sv * C57BL/6	MGI:3837032
cn3	Il6st^tm1Ern/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N	MGI:3837205
cx4	Il6st^tm1Ern/Il6st^tm1Ern Stat3^tm1Aki/Stat3⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:3837309
cx5	Il6st^tm1Ern/Il6st^tm1Ern Tirap^tm1.1Pjh/Tirap^tm1.1Pjh	involves: 129S1/Sv	MGI:4939800
cx6	Il6st^tm1Ern/Il6st^tm1Ern Stat1^tm1Rds/Stat1^tm1Rds	involves: 129S1/Sv	MGI:3837310
cx7	Ifnar2^tm1Pjh/Ifnar2^tm1Pjh Il6st^tm1Ern/Il6st^tm1Ern	involves: 129S1/Sv	MGI:4939801
cx8	Il6^tm1Kopf/Il6^tm1Kopf Il6st^tm1Ern/Il6st^tm1Ern	involves: 129S1/Sv * 129S2/SvPas	MGI:3837308
cx9	Il6st^tm1Ern/Il6st⁺ Smad3^tm1Par/Smad3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3837663
cx10	Il6st^tm1Ern/Il6st^tm1Ern Tg(RP11-H2112)9Trme/0	involves: 129S1/Sv * C57BL/6J * DBA/2J	MGI:5898092
cx11	Il6st^tm1Ern/Il6st^tm1Ern Tg(RP11-H2112)5Trme/0	involves: 129S1/Sv * C57BL/6J * DBA/2J	MGI:5898091
cx12	Gkn2^{tm1.1(KOMP)Vlcg}/Gkn2^{tm1.1(KOMP)Vlcg} Il6st^tm1Ern/Il6st^tm1Ern	involves: 129S1/Sv * C57BL/6NTac	MGI:5898089

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

immune system

increased neutrophil cell number ( J:168781 )

• LPS-treated mice exhibit a 4-fold increase in neutrophil influx into the peritoneal cavity with a 2-fold increase in the neutrophil-attractant CXCL11 compared with similarly treated wild-type mice

increased circulating interleukin-6 level ( J:168781 )

• LPS-treated mice exhibit a 3.5- and 2-fold (at 3 and 6 hours) increase in serum IL6 levels compared with similarly treated wild-type mice

increased interleukin-6 secretion ( J:168781 )

• LPS-treated mice exhibit a 3- and 34-fold (at 3 and 6 hours) increase in IL6 at the site of injection compared with similarly treated wild-type mice

increased susceptibility to endotoxin shock ( J:168781 )

• LPS-treated mice exhibit an increase in serum IL6 (3.5-fold at 3 hours, 2-fold at 6 hours), IL6 secretion into the peritoneal cavity (3-fold at 3 hours, 32-fold at 6 hours), neutrophil infiltration into the peritoneal cavity, and increased mortality compared with similarly treated wild-type mice

• however, LPS-induced IL10 production is normal

homeostasis/metabolism

increased circulating interleukin-6 level ( J:168781 )

• LPS-treated mice exhibit a 3.5- and 2-fold (at 3 and 6 hours) increase in serum IL6 levels compared with similarly treated wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

hematopoietic system

increased neutrophil cell number ( J:168781 )

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:79073 )

• age dependent enlargement of the proximal small intestine starting around 6-8 weeks of age

abnormal stomach morphology ( J:79073 )

abnormal stomach mucosa morphology ( J:79073 , J:87206 )

• hyperproliferative lesions in the antropyloric mucosa (J:79073)

• gastric outlet obstruction (J:79073)

• fewer mucus producing cells (J:79073)

• enlarged glandular structure with increased branching (J:79073)

• infiltrating lymphocytes abundant in the lamina propria and intraepithelial compartments (J:79073)

• non adenomatous stomach is hyperplastic with more pronounced rugae (J:87206)

• total area is increased from 16 weeks of age onward (J:87206)

enlarged stomach ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

abnormal digestive system physiology ( J:87206 )

decreased susceptibility to induced colitis ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

increased stomach pH ( J:87206 )

• in mice over 20 weeks of age

stomach inflammation ( J:87206 )

• gastritis is seen in all adults

• mixed mononuclear cells and polymorphonuclear leukocytes involved

immune system

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

increased osteoclast cell number ( J:87612 )

abnormal inflammatory response ( J:139226 )

• neutrophil infiltration of the peritoneal cavity peaks more rapidly in induced inflammation than in controls (6 vs 12 hrs)

• neutrophils cleared more rapidly than in controls in induced inflammation

decreased susceptibility to induced colitis ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

stomach inflammation ( J:87206 )

• gastritis is seen in all adults

• mixed mononuclear cells and polymorphonuclear leukocytes involved

increased susceptibility to induced arthritis ( J:142883 )

• increased overall severity of arthritis induced with methylated bovine serum albumin

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

neoplasm

increased adenoma incidence ( J:79073 , J:87206 )

• presence of pseudopolyploid diffuse adenomatous lesions in the stomach (J:79073)

• become larger and more numerous with age (J:87206)

• involve dysplastic cells and branching tortuous gastric glands (J:87206)

skeleton

increased osteoclast cell number ( J:87612 )

increased susceptibility to induced arthritis ( J:142883 )

• increased overall severity of arthritis induced with methylated bovine serum albumin

decreased compact bone thickness ( J:87612 )

increased osteoblast cell number ( J:87612 )

• on trabecular bone surfaces

abnormal trabecular bone morphology ( J:87612 )

• trabecular numbers reduced, particularly in males

decreased trabecular bone thickness ( J:87612 )

• trabecular thickness reduced, particularly in males

hematopoietic system

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

increased osteoclast cell number ( J:87612 )

growth/size/body

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:87206

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Il6st^tm1Wme mutation (2 available); any Il6st mutation (80 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:97327 )

N	• do not suffer liver damage from ConA treatment if pretreated with Il6

abnormal liver regeneration ( J:135290 )

• maximal DNA synthesis in hepatocytes after partial hepatectomy occurs after about 48 hours

• hepatocyte growth factor has no effect on hepatocyte proliferation unless administered with Il6

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Stat3^tm1Aki/Stat3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:100160 )

N	• improved survival

immune system

immune system phenotype ( J:100160 , J:139226 , J:142883 )

N	• splenomegaly fails to develop (J:100160) • neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal (J:139226) • response to arthritis induced with methylated serum albumin is comparable to control animals (J:142883)

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• compared with LPS-treated Il6st^tm1Ern homozygotes

digestive/alimentary system

digestive/alimentary phenotype ( J:100160 )

N	• stomach size remains normal

neoplasm

neoplasm ( J:100160 )

N	• numbers of gastric adenomas is reduced

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Tirap^tm1.1Pjh/Tirap^tm1.1Pjh
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Tirap^tm1.1Pjh mutation (0 available); any Tirap mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• LPS-treated mice exhibit increased survival and decreased serum IL6 compared with similarly treated Il6st^tm1Ern homozygotes

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Stat1^tm1Rds/Stat1^tm1Rds
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Stat1^tm1Rds mutation (4 available); any Stat1 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:139226 )

• neutrophil infiltration of the peritoneal cavity peaks more rapidly in induced inflammation than in controls

• neutrophils cleared more rapidly than in controls in induced inflammation

Allelic Composition	Ifnar2^tm1Pjh/Ifnar2^tm1Pjh Il6st^tm1Ern/Il6st^tm1Ern
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar2^tm1Pjh mutation (4 available); any Ifnar2 mutation (42 available)
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

immune system

increased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice

increased susceptibility to endotoxin shock ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

• LPS-treated mice exhibit an increase in IL6 serum levels compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:168781 )

• mice fail to survive beyond 72 hours after treatment with an LPS dose that is sub-lethal to wild-type mice

Allelic Composition	Il6^tm1Kopf/Il6^tm1Kopf Il6st^tm1Ern/Il6st^tm1Ern
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Il6^tm1Kopf mutation (9 available); any Il6 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:139226 )

N	• neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal

decreased susceptibility to endotoxin shock ( J:168781 )

• mice are resistant to LPS-induced shock

Allelic Composition	Il6st^tm1Ern/Il6st⁺ Smad3^tm1Par/Smad3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Smad3^tm1Par mutation (2 available); any Smad3 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased adenoma incidence ( J:100160 )

• develop antral adenomas by 13-24 weeks of age

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Tg(RP11-H2112)9Trme/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Tg(RP11-H2112)9Trme mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:234656 )

• decrease in the overall thickness of the antral mucosa compared to mice homozygous for the Il6st mutation not carrying the transgene

decreased stomach tumor incidence ( J:234656 )

• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

hematopoietic system

abnormal spleen size ( J:234656 )

• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene

neoplasm

decreased stomach tumor incidence ( J:234656 )

• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

immune system

abnormal spleen size ( J:234656 )

• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Tg(RP11-H2112)5Trme/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Tg(RP11-H2112)5Trme mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:234656 )

• decrease in the overall thickness of the antral mucosa compared to mice homozygous for the Il6st mutation not carrying the transgene

decreased stomach tumor incidence ( J:234656 )

• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

hematopoietic system

abnormal spleen size ( J:234656 )

• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene

neoplasm

decreased stomach tumor incidence ( J:234656 )

• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

immune system

abnormal spleen size ( J:234656 )

• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene

Allelic Composition	Gkn2^{tm1.1(KOMP)Vlcg}/Gkn2^{tm1.1(KOMP)Vlcg} Il6st^tm1Ern/Il6st^tm1Ern
Genetic Background	involves: 129S1/Sv * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gkn2^{tm1.1(KOMP)Vlcg} mutation (1 available); any Gkn2 mutation (22 available)
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:234656 )

• corpus tumors display poorly differentiated and hyperplastic epithelium histologically

increased stomach mucosa thickness ( J:234656 )

• in the corpus mucosa as a result of tumor formation

• however, antral mucosa thickness is similar to Il6st single mutants

increased stomach tumor incidence ( J:234656 )

• unlike Il6st single mutants which develop primarily antral tumors, double mutants show extensive focal tumorigenesis of the corpus and squamous epithelium overlying the limiting ridge of the corpus/forestomach junction at 12 weeks of age

• increase in both the number of corpus tumor foci and macroscopic corpus tumor area

• however, antral tumor load is similar to Il6st single mutants

neoplasm

increased stomach tumor incidence ( J:234656 )

• increase in both the number of corpus tumor foci and macroscopic corpus tumor area

• however, antral tumor load is similar to Il6st single mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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