Phenotypes associated with this allele

• Allele Symbol: Pmp22^Tr-3H
• Allele Name: trembler 3 Harwell
• Allele ID: MGI:2388488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pmp22^Tr-3H/Pmp22^+	involves: BALB/c * C3H/HeH	MGI:3794519

Genotype
MGI:3794519

ht1

• Allelic Composition: Pmp22^Tr-3H/Pmp22⁺
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:79382 )

• mice exhibit resting tremors beginning at 3 weeks of age

abnormal motor coordination/balance ( J:79382 )

• impaired motor function is less severe than in Pmp22^Tr-1H or Pmp22^Tr-2H heterozygotes

impaired righting response ( J:79382 )

impaired coordination ( J:79382 )

• when suspended by their tails mice exhibit repeated extension and flexion of their hindlimbs unlike wild-type mice

• in a hanging wire test mice fail to grasp with hindlimbs and fall unlike wild-type mice

decreased grip strength ( J:79382 )

abnormal gait ( J:79382 )

decreased locomotor activity ( J:79382 )

nervous system

abnormal Schwann cell morphology ( J:79382 )

• Schwann cell numbers are increased compared to in wild-type mice but not as severely as in Pmp22^Tr-1H or Pmp22^Tr-2H heterozygotes

axon degeneration ( J:79382 )

• mice exhibit axonal atrophy

demyelination ( J:79382 )