Phenotypes associated with this allele

• Allele Symbol: Hoxd3^{tm3(Hoxa3)Mrc}
• Allele Name: targeted mutation 3, Mario R Capecchi
• Allele ID: MGI:2388516
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd3^tm3(Hoxa3)Mrc/Hoxd3^tm3(Hoxa3)Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3836910
ht2	Hoxd3^tm2Mrc/Hoxd3^tm3(Hoxa3)Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3836911
cx3	Hoxa3^tm1Kth/Hoxa3^tm1Kth Hoxd3^tm3(Hoxa3)Mrc/Hoxd3^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3836907

Genotype
MGI:3836910

hm1

• Allelic Composition: Hoxd3^{tm3(Hoxa3)Mrc}/Hoxd3^{tm3(Hoxa3)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:60296 )

N • normal atlas

N • normal axis

Genotype
MGI:3836911

ht2

• Allelic Composition: Hoxd3^tm2Mrc/Hoxd3^{tm3(Hoxa3)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal cervical atlas morphology ( J:60296 )

• partially restored

abnormal arcus anterior morphology ( J:60296 )

• anterior arch sometimes incomplete

abnormal odontoid process morphology ( J:60296 )

• partially restored

fusion of atlas and odontoid process ( J:60296 )

• dens of sometimes fused to the anterior arch of the atlas

Genotype
MGI:3836907

cx3

• Allelic Composition: Hoxa3^tm1Kth/Hoxa3^tm1Kth; Hoxd3^{tm3(Hoxa3)Mrc}/Hoxd3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality ( J:60296 )

immune system

athymia ( J:60296 )

craniofacial

abnormal hyoid bone morphology ( J:60296 )

• malformed

skeleton

abnormal hyoid bone morphology ( J:60296 )

• malformed

hematopoietic system

athymia ( J:60296 )

endocrine/exocrine glands

athymia ( J:60296 )