Phenotypes associated with this allele

• Allele Symbol: Rr282726^tm1Dhr
• Allele Name: targeted mutation 1, David H Raulet
• Allele ID: MGI:2388606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr282726^tm1Dhr/Rr282726^tm1Dhr	involves: 129S4/SvJae * C57BL/6	MGI:3813520

Genotype
MGI:3813520

hm1

• Allelic Composition: Rr282726^tm1Dhr/Rr282726^tm1Dhr
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is slightly reduced in the adult thymus

abnormal gamma-delta T cell differentiation ( J:75624 )

• there is a 30-40% reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2

• there is a 3- to 4- fold reduction in the number Vgamma2 expressing gammadelta T cells in the periphery

hematopoietic system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is slightly reduced in the adult thymus

abnormal gamma-delta T cell differentiation ( J:75624 )

• there is a 30-40% reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2

• there is a 3- to 4- fold reduction in the number Vgamma2 expressing gammadelta T cells in the periphery