Phenotypes associated with this allele

• Allele Symbol: Rr275254^tm2Dhr
• Allele Name: targeted mutation 2, David H Raulet
• Allele ID: MGI:2388607
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr275254^tm2Dhr/Rr275254^tm2Dhr	involves: 129S4/SvJae	MGI:3813517

Genotype
MGI:3813517

hm1

• Allelic Composition: Rr275254^tm2Dhr/Rr275254^tm2Dhr
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is reduced by 2.6-fold in the adult thymus

• Vgamma3 and Vgamma4 rearrangments are reduced by 2- to 4-fold in fetal thymocytes

abnormal gamma-delta T cell differentiation ( J:75624 )

• there is a 15-fold reduction reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2

• there is about a 20-fold reduction in precursor gammadelta T cells expressing Vgamma3 among E15 fetal thymocytes and a 5- to 10- fold reduction among E17 fetal thymocytes

hematopoietic system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is reduced by 2.6-fold in the adult thymus

• Vgamma3 and Vgamma4 rearrangments are reduced by 2- to 4-fold in fetal thymocytes

abnormal gamma-delta T cell differentiation ( J:75624 )

• there is a 15-fold reduction reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2

• there is about a 20-fold reduction in precursor gammadelta T cells expressing Vgamma3 among E15 fetal thymocytes and a 5- to 10- fold reduction among E17 fetal thymocytes