Phenotypes associated with this allele

• Allele Symbol: Foxg1^tm1(tTA)Lai
• Allele Name: targeted mutation 1, Eseng Lai
• Allele ID: MGI:2388671
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxg1^tm1(tTA)Lai/Foxg1^+ Tg(tetO-Gsx2,-EGFP)1Kc/0	involves: 129S1/Sv	MGI:4412090
cx2	Foxg1^tm1(tTA)Lai/Foxg1^tm1M Tg(tetO-Foxg1)1Lai/0	involves: 129S1/Sv * C57BL/6	MGI:2451132

Genotype
MGI:4412090

cx1

• Allelic Composition: Foxg1^tm1(tTA)Lai/Foxg1⁺; Tg(tetO-Gsx2,-EGFP)1Kc/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:154936 )

• mice exhibit abnormal brain morphology during embryogenesis that is severe after E15.5

• however, doxycycline-treated mice exhibit improved brain morphology

abnormal telencephalon development ( J:154936 )

• mice exhibit an increase in the expression of ventral telencephalic markers throughout the pallium compared with Tg(tetO-Gsx2,-EGFP)1Kcam mice

abnormal olfactory bulb morphology ( J:154936 )

abnormal lateral ganglionic eminence morphology ( J:154936 )

• after E13.5, mice exposed to doxycycline between E7 and E9 exhibit expansion of the dorsal lateral ganglionic eminence, as determined by marker expression, compared with Tg(tetO-Gsx2,-EGFP)1Kcam mice

Genotype
MGI:2451132

cx2

• Allelic Composition: Foxg1^tm1(tTA)Lai/Foxg1^tm1M; Tg(tetO-Foxg1)1Lai/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

nervous system

nervous system phenotype ( J:78115 )

N • size of the neocortex and proliferation of progenitor cells throughout the dorsal telencephalon are restored to normal levels by expression of the mutant protein

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

abnormal basal ganglion morphology ( J:78115 )

• absent

abnormal telencephalon morphology ( J:78115 )

• dorsomedial telencephalon is abnormal

embryo

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

cellular

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle