All Phenotypes Oprm1<tm1Loh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Loh/Oprm1^tm1Loh	involves: 129P2/OlaHsd	MGI:3625861
hm2	Oprm1^tm1Loh/Oprm1^tm1Loh	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3619218
hm3	Oprm1^tm1Loh/Oprm1^tm1Loh	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J	MGI:3619220
hm4	Oprm1^tm1Loh/Oprm1^tm1Loh	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3625887
ht5	Oprm1^tm1Loh/Oprm1⁺	involves: 129P2/OlaHsd	MGI:3625879

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• a dose of morphine (400 mg/kg) that is lethal to wild-type mice did not cause death of any mutant animals; the LD50 of morphine in homozygotes is much higher than 800 mg/kg

• homozygotes die within 2 hours at doses of 1600 mg/kg without typical morphine effects, suggesting reasons other than morphine toxicity

behavior/neurological

enhanced behavioral response to cocaine ( J:107973 )

• repeated administration of cocaine induces robust behavioral sensitization in mutant mice on day6 which is maintained through day 12: acute cocaine treatment significantly decreases locomotor activity in mutants

impaired behavioral response to morphine ( J:47187 , J:107973 )

• at 800 mg/kg of morphine, homozygotes do not display the usual morphine effects like Straub tail or increased locomotor activity, like heterozygotes (J:47187)

• repeated administration of morphine fails to induce behavioral sensitization in mutant mice on days 6 and 12; locomotor activity in response to morphine is similar to saline treatment on day 1 (J:107973)

abnormal spatial learning ( J:85653 )

• null mice exhibit memory impairment in both the hidden platform and probe trial paradigms of the Morris water maze test

decreased chemically-elicited antinociception ( J:47187 )

• ED50 of morphine in wild-type is 3.67 mg/kg and 419.9 mg/kg in homozygotes; the drug has no analgesic effect in mutants

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• a dose of morphine (400 mg/kg) that is lethal to wild-type mice did not cause death of any mutant animals; the LD50 of morphine in homozygotes is much higher than 800 mg/kg

• homozygotes die within 2 hours at doses of 1600 mg/kg without typical morphine effects, suggesting reasons other than morphine toxicity

Allelic Composition	Oprm1^tm1Loh/Oprm1^tm1Loh
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Loh mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:61244 )

• in slices from the dentate gyrus of mutants, only a small and short-lasting potentiaton of the population spike and the fEPSP, compared with wild-type mice

reduced long-term potentiation ( J:61244 )

• application of a mu-opioid receptor antagonist decreased, LTP is depressed in the dentate gyrus of wild-type mice, but there is no effect in mutants

Allelic Composition	Oprm1^tm1Loh/Oprm1^tm1Loh
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Loh mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:106367 )

• female mutants show ethanol-induced FOS reactivity in the GP and VP that is not seen in wild-type; FOS reactivity is seen in wild-type in the LSV, SCh, LGN and DGN but not in mutants in response to ethanol

Allelic Composition	Oprm1^tm1Loh/Oprm1^tm1Loh
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Loh mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:106857 )

• oral administration of metformin does not affect plasma glucose in Oprm1-deficient diabetic mice 8-10 weeks of age but does lower glucose levels by ~21% in wild-type diabetic mice; in null mice and wild-type mice, beta-endorphin is elevated in the plasma with metformin treatment

Allelic Composition	Oprm1^tm1Loh/Oprm1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Loh mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• the LD50 of morphine in heterozygotes is 800 mg/kg, compared to 400 mg/kg for wild-type

behavior/neurological

decreased chemically-elicited antinociception ( J:47187 )

• ED50 of morphine in wild-type is 3.67 mg/kg and 4.49 mg/kg in heterozygotes

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• the LD50 of morphine in heterozygotes is 800 mg/kg, compared to 400 mg/kg for wild-type

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