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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2Mok
targeted mutation 2, Motoya Katsuki
MGI:2388703
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2Mok/Trp53tm2Mok involves: 129S/SvEv * C57BL/6 MGI:4438456
ht2
 		Trp53tm2Mok/Trp53+ involves: 129S/SvEv * C57BL/6 MGI:3625002
cx3
 		Cdc7tm1Hmas/Cdc7tm1Hmas
Trp53tm2Mok/Trp53tm2Mok 		involves: 129S/Sv * C57BL/6 MGI:2662267
cx4
 		Hipk1tm1Hko/Hipk1tm1Hko
Hipk2tm1Hko/Hipk2tm1Hko
Trp53tm2Mok/Trp53+ 		involves: 129S/SvEv * C57BL/6 MGI:3625003


Genotype
MGI:4438456
hm1
Allelic
Composition		 Trp53tm2Mok/Trp53tm2Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm




Genotype
MGI:3625002
ht2
Allelic
Composition		 Trp53tm2Mok/Trp53+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Mok mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:106931 )
• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type




Genotype
MGI:2662267
cx3
Allelic
Composition		 Cdc7tm1Hmas/Cdc7tm1Hmas
Trp53tm2Mok/Trp53tm2Mok
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7tm1Hmas mutation (0 available); any Cdc7 mutation (34 available)
Trp53tm2Mok mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo

growth/size/body
decreased embryo size ( J:76497 )




Genotype
MGI:3625003
cx4
Allelic
Composition		 Hipk1tm1Hko/Hipk1tm1Hko
Hipk2tm1Hko/Hipk2tm1Hko
Trp53tm2Mok/Trp53+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation (0 available); any Hipk1 mutation (61 available)
Hipk2tm1Hko mutation (0 available); any Hipk2 mutation (55 available)
Trp53tm2Mok mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:106931 )
• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory