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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k8tm1Pnt
targeted mutation 1, Phillip Tsichlis
MGI:2388714
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k8tm1Pnt/Map3k8tm1Pnt involves: 129S1/Sv MGI:3822911
hm2
 		Map3k8tm1Pnt/Map3k8tm1Pnt involves: 129S1/Sv * C57BL/6J MGI:2389024
cx3
 		Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+ 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629606
cx4
 		Map3k8tm1Pnt/Map3k8tm1Pnt
Nfkb1tm1Sley/Nfkb1tm1Sley 		involves: 129S1/Sv * 129S4/SvJae MGI:5491301


Genotype
MGI:3822911
hm1
Allelic
Composition		 Map3k8tm1Pnt/Map3k8tm1Pnt
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:142340 , J:196528 )
N
• there is no difference from controls in the number or percentage of regulatory T cells, CD4+ and CD8+ memory T cells, and NKT cells found in the thymus and spleen (J:142340)
• the proliferative response of nave CD4+ T cells to TCR stimulation is also normal (J:142340)
• mice exhibit normal IL12b secretion and circulating levels (J:196528)




Genotype
MGI:2389024
hm2
Allelic
Composition		 Map3k8tm1Pnt/Map3k8tm1Pnt
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:66503 )
N
• bone marrow, thymus, spleen and lymph nodes are hystologically normal and contain the all the expected cell subsets in normal ratios, mice show normal antibody responses to T-cell dependent antigen KLH and to T-cell independent antigens LPS-TNP, and T-cell mediated cytotoxic response against LCMV infected cells is normal
decreased tumor necrosis factor secretion ( J:66503 )
• in response to LPS mice secrete less TNF-alpha
• splenocytes, thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages are defective in TNF-alpha induction following LPS stimulation
decreased susceptibility to endotoxin shock ( J:66503 )
• mice were resistant to the induction of endotoxin shock




Genotype
MGI:3629606
cx3
Allelic
Composition		 Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:108572 )
• there is a delayed onset and significant attenuation of disease compared to controls
increased CD8-positive, alpha-beta T cell number ( J:108572 )
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls
increased single-positive T cell number ( J:108572 )
• there is a significant increase in numbers of CD4+ and CD8+ cells

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:108572 )
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls
increased single-positive T cell number ( J:108572 )
• there is a significant increase in numbers of CD4+ and CD8+ cells

digestive/alimentary system
small intestinal inflammation ( J:108572 )
• there is a delayed onset and significant attenuation of disease compared to controls




Genotype
MGI:5491301
cx4
Allelic
Composition		 Map3k8tm1Pnt/Map3k8tm1Pnt
Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
Nfkb1tm1Sley mutation (0 available); any Nfkb1 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-12b secretion ( J:196528 )
• in bone marrow-derived macrophage
decreased tumor necrosis factor secretion ( J:196528 )
• from bone marrow-derived macrophage stimulated with LPS
• from primary peritoneal macrophages from mice stimulated with LPS

homeostasis/metabolism




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory