Analysis Tools|
Allele Symbol Allele Name Allele ID |
Foxd3tm2Lby targeted mutation 2, Patricia A Labosky MGI:2388721 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• phenotype is stated to be the same as in Foxd3tm1Lby however, no data is shown in J:79491
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• labyrinthine precursors are absent
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• giant cells are produced but the spongiotrophoblast lineage is absent
• marker analysis indicates that the fate of trophoblast precursor cells is shifted towards production of giant cells and away from development of spongiotrophoblast and labyrinthine lineages
• undifferentiated trophoectodermal cells are present at E8.0 but absent by E9.0 indicating a failure to maintain the multipotent progenitor cell population
• unable to derive trophoblast stem cell lines from E3.5 embryos or E6.5 extraembryonic ectoderm
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• the spongiotrophoblast lineage is absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• live embryos were found in the expected ratios at all times in development but no mutant mice survived more than a few hours
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• cranial defects are observed at midgestation stages
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• the basioccipital bone is present but smaller in size
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• the frontal bone is missing
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• the interparietal bone is greatly reduced in size
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• the parietal bone is greatly reduced in size
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• the mandible is thickened
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• the mandible is shortened
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• the nasal capsule is missing
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• reduced in size and striking decrease of neural crest cells
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• all mutant mice had a severe cleft face and palate incompatible with survival
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• the facial midline never fused
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• all mutant mice had a severe cleft face and palate incompatible with survival
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• the nasal capsule is missing
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• due to severe cleft face and palate, mutant mice were unable to breathe after birth
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• the eyelids were partially open at birth
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• cranial defects are observed at midgestation stages
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• the basioccipital bone is present but smaller in size
|
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• the frontal bone is missing
|
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• the interparietal bone is greatly reduced in size
|
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• the parietal bone is greatly reduced in size
|
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• the mandible is thickened
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• the mandible is shortened
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• the nasal capsule is missing
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• fewer neural crest cells entering the heart field
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• no mutant neural crest cells entered the developing gut
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• reduced in size and striking decrease of neural crest cells
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• the neurons and glia in enteric nerves system derived from neural crest cell are absent
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• spinal nerves along the trunk of the mutant embryos were thinner
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• spinal nerves exiting the dorsal root ganglia are absent
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• a duplication of the left common carotid artery
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• fewer neural crest cells entering the heart field
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• increased apoptotic cells in the dorsal spinal cord, in the hindbrain, and in the posterior tail
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• fewer neural crest cells entering the heart field
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• no mutant neural crest cells entered the developing gut
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• the nasal capsule is missing
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• all mutant mice had a severe cleft face and palate incompatible with survival
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• the facial midline never fused
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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