Phenotypes associated with this allele

• Allele Symbol: Afp^tm1Ibmm
• Allele Name: targeted mutation 1, Claude Szpirer
• Allele ID: MGI:2388722
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Afp^tm1Ibmm/Afp^tm1Ibmm	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)	MGI:2450139

Genotype
MGI:2450139

hm1

• Allelic Composition: Afp^tm1Ibmm/Afp^tm1Ibmm
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sexual interaction ( J:79500 )

♀ • failure to mate; vaginal plugs were undetected, indicating lack of mating

♀ • lack of mating putatively due to defective estrous cycle

♀ • males fertile

failure of copulatory plug deposition ( J:79500 )

• vaginal plugs were undetected, indicating lack of mating

endocrine/exocrine glands

abnormal ovary morphology ( J:79500 )

♀ • smooth surface, suggesting failure to ovulate

absent corpus luteum ( J:79500 )

♀

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:79500 )

increased circulating luteinizing hormone level ( J:79500 )

decreased circulating progesterone level ( J:79500 )

• normal serum estradiol levels

reproductive system

abnormal ovary morphology ( J:79500 )

♀ • smooth surface, suggesting failure to ovulate

absent corpus luteum ( J:79500 )

♀

endometrium hyperplasia ( J:79500 )

♀ • endometrial hyperplasia observed in 4 wk old (prepubertal) and 12 wk old (adult) mice, putatively due to estrogen sensitivity

♀ • uterine horns normal in 1 wk old mice

anovulation ( J:79500 )

♀ • absent, but normal pre-ovulatory Graafian follicles; ovulations were artificially induced by gonadatropins, though this did not rescue the infertility phenotype, putatively due to failed implanation

absent estrous cycle ( J:79500 )

♀ • lack of mating putatively due to defective estrous cycle

female infertility ( J:79500 )

♀ • vaginal plugs were undetected, indicating lack of mating

♀ • lack of mating putatively due to defective estrous cycle

♀ • males fertile