Phenotypes associated with this allele

• Allele Symbol: Tnfsf4^tm1Sug
• Allele Name: targeted mutation 1, Kazuo Sugamura
• Allele ID: MGI:2388724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf4^tm1Sug/Tnfsf4^tm1Sug	B6.129S4-Tnfsf4^tm1Sug	MGI:2651597

Genotype
MGI:2651597

hm1

• Allelic Composition: Tnfsf4^tm1Sug/Tnfsf4^tm1Sug
• Genetic Background: B6.129S4-Tnfsf4^tm1Sug

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response

decreased susceptibility to type IV hypersensitivity reaction ( J:80214 )

• decreased ear swelling 24 hours following challenge with 4-dinitrofluorobenzene (DNFB), 6-trinitrochlorobenzene (TNCB), and FITC compared to wild-type

abnormal cytokine secretion ( J:80214 )

• reduced hapten-specific T cell proliferative response; however, migratory responses are normal

hematopoietic system

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response

cellular

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response