All Phenotypes Il12a<tm1Cab> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il12a^tm1Cab
targeted mutation 1, Christine A Biron
MGI:2388729

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il12a^tm1Cab/Il12a^tm1Cab	B6.129S4-Il12a^tm1Cab	MGI:3813922
hm2	Il12a^tm1Cab/Il12a^tm1Cab	involves: 129S4/SvJae * C57BL/6	MGI:3813911
cx3	Il12a^tm1Cab/Il12a^tm1Cab Il23a^tm1.1Thak/Il23a^tm1.1Thak	B6.Cg-Il12a^tm1Cab Il23a^tm1.1Thak	MGI:3830543

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab
Genetic Background	B6.129S4-Il12a^tm1Cab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell physiology ( J:79552 )

• there is 4-fold less NK cells in MCMV infected mice that are producing IFN-gamma than in controls

decreased circulating interferon-gamma level ( J:79552 )

• 1.5 days after MCMV infection, IFN-gamma levels in serum are about 40-fold lower than in controls

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:79552 )

• 1.5 days after MCMV infection, IFN-gamma levels in serum are about 40-fold lower than in controls

hematopoietic system

abnormal NK cell physiology ( J:79552 )

• there is 4-fold less NK cells in MCMV infected mice that are producing IFN-gamma than in controls

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interferon-gamma level ( J:54482 )

• IFN-gamma levels are not detectable in serum 36 hours after LCMV infection

decreased circulating interleukin-12 level ( J:54482 )

• IL-12 heterodimer levels are absent from serum 2.5- and 5- hours after LPS injection or 36 hours after LCMV infection

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:54482 )

• IFN-gamma levels are not detectable in serum 36 hours after LCMV infection

decreased circulating interleukin-12 level ( J:54482 )

• IL-12 heterodimer levels are absent from serum 2.5- and 5- hours after LPS injection or 36 hours after LCMV infection

Allelic Composition	Il12a^tm1Cab/Il12a^tm1Cab Il23a^tm1.1Thak/Il23a^tm1.1Thak
Genetic Background	B6.Cg-Il12a^tm1Cab Il23a^tm1.1Thak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12a^tm1Cab mutation (0 available); any Il12a mutation (35 available)
Il23a^tm1.1Thak mutation (0 available); any Il23a mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:143970 )

• mice are susceptible to EAE when they are recipients of activated CD4⁺ T cells isolated from MOG-immunized mice with slightly less inflammation occurring in the cervical spinal cord

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