Analysis Tools
homeostasis/metabolism
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• there is no detectable IFN-gamma in serum 1.5 days after MCMV infection compared to the mean 2578 pg/ml detected in wild-type mice
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immune system
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• proportions and numbers of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are decreased more than 60%
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• there is no detectable IFN-gamma in serum 1.5 days after MCMV infection compared to the mean 2578 pg/ml detected in wild-type mice
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• restimulation of lymphocytes from Ova-immunized mice solicits a greater IL-4 response than in controls
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• mice are less susceptible to low dose streptozotocin (STZ)-induced diabetes than controls
• mice start to develop diabetes on day 16 post first STZ-injection with a median diabetes-free survival of 20 days compared to 7 days for start of diabetes and a median diabetes-free survival of 9 days for wild-type mice
• mice show a markedly milder form of disease with a lower level of blood glucose throughout the entire observation time compared to wild-type littermates
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hematopoietic system
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• proportions and numbers of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are decreased more than 60%
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