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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elf4tm1Nim
targeted mutation 1, Stephen D Nimer
MGI:2388892
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elf4tm1Nim/Elf4tm1Nim B6.129S1-Elf4tm1Nim MGI:3620623


Genotype
MGI:3620623
hm1
Allelic
Composition		 Elf4tm1Nim/Elf4tm1Nim
Genetic
Background		 B6.129S1-Elf4tm1Nim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf4tm1Nim mutation (0 available); any Elf4 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:79568 )
• T-cell transition from DN3 to DN4 stage is slightly enhanced in the thymus
increased B cell number ( J:79568 )
• modest increase in B to T cell ratio in lymph nodes and spleen
decreased NK cell number ( J:79568 )
• reduced 60% in spleen
decreased NK T cell number ( J:79568 )
• reduced production of thymic NK-T cells
increased B cell proliferation ( J:79568 )
• increased proliferative response of splenic B cells to LPS
increased T cell proliferation ( J:79568 )
• modest increase in T cell proliferation in response to TCR crosslinking
abnormal NK cell physiology ( J:79568 )
• reduced ability to produce IFNgamma
impaired natural killer cell mediated cytotoxicity ( J:79568 )
• unable to kill tumor cell targets
decreased cytotoxic T cell cytolysis ( J:79568 )
• cytolytic activity of CD8+ T cells significantly reduced
large lymphoid organs ( J:79568 )
• mice over 1 year in age sometimes display enlargement of secondary lymphoid organs
abnormal inflammatory response ( J:79568 )
• mice over 1 year in age often with lymphocytic infiltrates around blood vessels of the lung, kidney, and myometrium of the uterus

hematopoietic system
abnormal definitive hematopoiesis ( J:107070 )
• recover rapidly from myeloablative treatment
abnormal hematopoietic stem cell morphology ( J:107070 )
• hematopoietic stem cells with impaired proliferative properties
increased hematopoietic stem cell number ( J:107070 )
• five fold increase in primitive hematopoietic progenitors rather than committed progenitor cell lines
abnormal T cell differentiation ( J:79568 )
• T-cell transition from DN3 to DN4 stage is slightly enhanced in the thymus
increased B cell number ( J:79568 )
• modest increase in B to T cell ratio in lymph nodes and spleen
decreased NK cell number ( J:79568 )
• reduced 60% in spleen
decreased NK T cell number ( J:79568 )
• reduced production of thymic NK-T cells
increased B cell proliferation ( J:79568 )
• increased proliferative response of splenic B cells to LPS
increased T cell proliferation ( J:79568 )
• modest increase in T cell proliferation in response to TCR crosslinking
abnormal NK cell physiology ( J:79568 )
• reduced ability to produce IFNgamma
impaired natural killer cell mediated cytotoxicity ( J:79568 )
• unable to kill tumor cell targets
decreased cytotoxic T cell cytolysis ( J:79568 )
• cytolytic activity of CD8+ T cells significantly reduced

cellular
increased B cell proliferation ( J:79568 )
• increased proliferative response of splenic B cells to LPS
increased T cell proliferation ( J:79568 )
• modest increase in T cell proliferation in response to TCR crosslinking




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory