Phenotypes associated with this allele

• Allele Symbol: Canx^tm1Den
• Allele Name: targeted mutation 1, Angela Denzel
• Allele ID: MGI:2388893
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Canx^tm1Den/Canx^tm1Den	involves: 129P2/OlaHsd * C57BL/6	MGI:2677259

Genotype
MGI:2677259

hm1

• Allelic Composition: Canx^tm1Den/Canx^tm1Den
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:79604 )

• half of the homozygous animals died within 48 hours of birth; most of the rest died within 4 weeks after birth with a few animals surviving to 3 months of age

behavior/neurological

novel environmental response-related retropulsion ( J:79604 )

ataxia ( J:79604 )

• truncal ataxia with increasing severity with age, less active in walking and splayed hind limbs

positive geotaxis ( J:79604 )

growth/size/body

decreased body size ( J:79604 )

• animals are smaller than littermates

nervous system

abnormal nervous system morphology ( J:79604 )

• decreased number of myelinated fibers in the sciatic nerve