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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfatc4tm1Jmk
targeted mutation 1, Jeffery D Molkentin
MGI:2388915
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfatc4tm1Jmk/Nfatc4tm1Jmk involves: 129S7/SvEvBrd * C57BL/6 MGI:3836576
cx2
 		Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk 		involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:3836581
cx3
 		Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(TIE2-lacZ)182Sato/? 		involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:3836582
cx4
 		Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/? 		involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB MGI:3836583
cx5
 		Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-Ppp3ca)37Eno/? 		involves: 129S7/SvEvBrd * C57BL/6 * FVB MGI:3836580


Genotype
MGI:3836576
hm1
Allelic
Composition		 Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:84138 )
N
• normal ventricular trabeculation
• normal thickening of compact zone
cardiac hypertrophy ( J:79608 )
• response to abdominal aortic constriction or continuous infusion of angiotensin II identical to controls
• increased heart weight/tibia length ratio when treated as above

growth/size/body
cardiac hypertrophy ( J:79608 )
• response to abdominal aortic constriction or continuous infusion of angiotensin II identical to controls
• increased heart weight/tibia length ratio when treated as above




Genotype
MGI:3836581
cx2
Allelic
Composition		 Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (71 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:84138 )
• embryos either necrotic or resorbed at E11.5
• no live embryos after E11.5

cardiovascular system
abnormal heart morphology ( J:84138 )
• thin and translucent at E10.5
• pericardial effusions
abnormal myocardium layer morphology ( J:84138 )
• more than 50% reduction in proliferation at E10.5
• no apoptosis
abnormal myocardial fiber mitochondrial morphology ( J:84138 )
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
abnormal myocardium compact layer morphology ( J:84138 )
• more than 50% reduction in the number of cells
abnormal heart development ( J:84138 )
• defects in cardiac development at E10.5
abnormal heart ventricle morphology ( J:84138 )
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
abnormal trabecula carnea morphology ( J:84138 )
• thinner
• fewer in number
dilated heart ( J:84138 )
• at E10.5
abnormal cardiovascular system physiology ( J:84138 )
• 30% reduction in mitochondrial respiration

cellular
abnormal myocardial fiber mitochondrial morphology ( J:84138 )
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
abnormal cellular respiration ( J:84138 )
• 30% reduction in mitochondrial respiration

hematopoietic system
anemia ( J:84138 )
• at E10.5

embryo
embryonic growth retardation ( J:84138 )
• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5

growth/size/body
embryonic growth retardation ( J:84138 )
• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5

muscle
abnormal myocardium layer morphology ( J:84138 )
• more than 50% reduction in proliferation at E10.5
• no apoptosis
abnormal myocardial fiber mitochondrial morphology ( J:84138 )
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
abnormal trabecula carnea morphology ( J:84138 )
• thinner
• fewer in number
abnormal myocardium compact layer morphology ( J:84138 )
• more than 50% reduction in the number of cells




Genotype
MGI:3836582
cx3
Allelic
Composition		 Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(TIE2-lacZ)182Sato/?
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (71 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
Tg(TIE2-lacZ)182Sato mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal dorsal aorta morphology ( J:84138 )
• reduced number of smooth muscle cells in the dorsal aorta but no hemorrhage




Genotype
MGI:3836583
cx4
Allelic
Composition		 Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/?
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (71 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
Tg(Myh6-NFATC4)#Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:84138 )
• viability extended to around E12
• no live embryos at E12.5 or later

cardiovascular system
cardiovascular system phenotype ( J:84138 )
N
• normal heart phenotype at E11.5
• heart mitochondrial respiration normal at E10.5
• 70% of mitochondria are normal in heart muscle at E10.5




Genotype
MGI:3836580
cx5
Allelic
Composition		 Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-Ppp3ca)37Eno/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardium layer morphology ( J:79608 )
• myofibrillar hypertrophy
cardiac hypertrophy ( J:79608 )
• identical to control mice with the transgene alone
• three fold increase in heart/body weight ratio
• wall thickening

muscle
abnormal myocardium layer morphology ( J:79608 )
• myofibrillar hypertrophy

growth/size/body
cardiac hypertrophy ( J:79608 )
• identical to control mice with the transgene alone
• three fold increase in heart/body weight ratio
• wall thickening




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory