About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bcantm1Ref
targeted mutation 1, Reinhard Fassler
MGI:2388924
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bcantm1Ref/Bcantm1Ref B6.Cg-Bcantm1Ref MGI:3046583
hm2
Bcantm1Ref/Bcantm1Ref either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) MGI:2656152


Genotype
MGI:3046583
hm1
Allelic
Composition
Bcantm1Ref/Bcantm1Ref
Genetic
Background
B6.Cg-Bcantm1Ref
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation (0 available); any Bcan mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• homozygotes exhibit normal spatial learning (water-maze test)
• homozygotes show normal motor coordination (rota-rod test)
• consistent with grossly normal hippocampal functions, acquisition and performance levels are only slightly, but insignificantly, reduced in the two-way active-avoidance paradigm
• other behavioral paradigms indicate normal gross sensory functions, reflexes, home cage activity, and food consumption




Genotype
MGI:2656152
hm2
Allelic
Composition
Bcantm1Ref/Bcantm1Ref
Genetic
Background
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation (0 available); any Bcan mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• homozygotes exhibit a normal brain anatomy; however, an up-regulation of chondroitin sulfate proteoglycan-3 (neurocan) protein is detected in the mutant forebrain
• the hippocampal CA1 region shows normal synapse distribution, frequency, and morphology
• basal properties and short-term plasticity of excitatory and inhibitory synapses to the pyramidal cells in the hippocampal CA1 region appear normal
• perineuronal nets are present around hippocampal nonpyramidal neurons in both wild-type and homozygous null mice; in mutants, however, the nets appear fuzzier and are less pronounced and less concentrated close to the plasma membrane
• homozygotes show significant defects in the maintenance of hippocampal LTP in brain slices, although the initial fEPSP slope is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory