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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bcantm1Ref
targeted mutation 1, Reinhard Fassler
MGI:2388924
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bcantm1Ref/Bcantm1Ref B6.Cg-Bcantm1Ref MGI:3046583
hm2
Bcantm1Ref/Bcantm1Ref either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) MGI:2656152


Genotype
MGI:3046583
hm1
Allelic
Composition
Bcantm1Ref/Bcantm1Ref
Genetic
Background
B6.Cg-Bcantm1Ref
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation (0 available); any Bcan mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• homozygotes exhibit normal spatial learning (water-maze test)
• homozygotes show normal motor coordination (rota-rod test)
• consistent with grossly normal hippocampal functions, acquisition and performance levels are only slightly, but insignificantly, reduced in the two-way active-avoidance paradigm
• other behavioral paradigms indicate normal gross sensory functions, reflexes, home cage activity, and food consumption




Genotype
MGI:2656152
hm2
Allelic
Composition
Bcantm1Ref/Bcantm1Ref
Genetic
Background
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation (0 available); any Bcan mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• homozygotes exhibit a normal brain anatomy; however, an up-regulation of chondroitin sulfate proteoglycan-3 (neurocan) protein is detected in the mutant forebrain
• the hippocampal CA1 region shows normal synapse distribution, frequency, and morphology
• basal properties and short-term plasticity of excitatory and inhibitory synapses to the pyramidal cells in the hippocampal CA1 region appear normal
• perineuronal nets are present around hippocampal nonpyramidal neurons in both wild-type and homozygous null mice; in mutants, however, the nets appear fuzzier and are less pronounced and less concentrated close to the plasma membrane
• homozygotes show significant defects in the maintenance of hippocampal LTP in brain slices, although the initial fEPSP slope is normal





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory