Phenotypes associated with this allele

• Allele Symbol: Csf3r^{tm4(Epor)Link}
• Allele Name: targeted mutation 4, Daniel C Link
• Allele ID: MGI:2388978
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csf3r^tm4(Epor)Link/Csf3r^tm4(Epor)Link	B6.129X1-Csf3r^tm4(Epor)Link	MGI:3836737
hm2	Csf3r^tm4(Epor)Link/Csf3r^tm4(Epor)Link	involves: 129X1/SvJ * C57BL/6	MGI:3836733

Genotype
MGI:3836737

hm1

• Allelic Composition: Csf3r^{tm4(Epor)Link}/Csf3r^{tm4(Epor)Link}
• Genetic Background: B6.129X1-Csf3r^{tm4(Epor)Link}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls

increased bone marrow cell number ( J:79567 )

• elevated bone marrow neutrophiles after treatment with granulocyte-colony stimulating factor (G-CSF)

decreased neutrophil cell number ( J:79567 )

• very few neutrophiles in the circulation after treatment with G-CSF

immune system

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls

decreased neutrophil cell number ( J:79567 )

• very few neutrophiles in the circulation after treatment with G-CSF

cellular

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls

Genotype
MGI:3836733

hm2

• Allelic Composition: Csf3r^{tm4(Epor)Link}/Csf3r^{tm4(Epor)Link}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

hematopoietic system

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced

abnormal common myeloid progenitor cell morphology ( J:79825 )

• bone marrow cells respond similarly to controls when treated with G-CSF

• colonies formed are smaller than with controls

• erythropoiesis and erythroid progenitors are unaffected

decreased granulocyte number ( J:79825 )

• numbers of mature granulocytes reduced to about 70% of controls

decreased neutrophil cell number ( J:79825 )

• number of circulating neutrophils about 15% of controls

• circulating neutrophiles show very little increase after treatment with granulocyte-colony stimulating factor (G-CSF)

immune system

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced

decreased granulocyte number ( J:79825 )

• numbers of mature granulocytes reduced to about 70% of controls

decreased neutrophil cell number ( J:79825 )

• number of circulating neutrophils about 15% of controls

• circulating neutrophiles show very little increase after treatment with granulocyte-colony stimulating factor (G-CSF)

cellular

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced