Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sirpatm1Nog targeted mutation 1, Tetsuya Noguchi MGI:2388979 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased immobility times in forced swimming tests
• active behavior becomes further suppressed in subsequent trials
• no abnormalities in other behavior tests including tail suspension tests
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Presence of megakaryocytes in the spleen of 11 week old Sirpatm1Nog/Sirpatm1Nog mice
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• mean body mass is reduced by about 10% compared to wild-type
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• an increased number of megakaryocytes are seen in the spleen at 11 weeks of age
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• the circulating platelet count is reduced by about 25% compared to wild-type mice
• the life span of platelets is significantly decreased in mutants
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• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice
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• the phagocytic activity of peritoneal macrophages is significantly enhanced
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• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice
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• the phagocytic activity of peritoneal macrophages is significantly enhanced
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• 2,4-dinitro-1-fluorobenzene-induced migration of Langerhans cells out of the epidermis is significantly impaired
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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