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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Idd3NOD
NOD
MGI:2389018
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Idd10NOD/ShiLt/Idd10NOD/ShiLt
Idd3NOD/Idd3NOD 		B6.NOD-Idd3NOD Idd10NOD/Lt MGI:3044052
ot2
 		Idd3NOD/? involves: C57BL/10 * NOD MGI:3036829


Genotype
MGI:3044052
cx1
Allelic
Composition		 Idd10NOD/ShiLt/Idd10NOD/ShiLt
Idd3NOD/Idd3NOD
Genetic
Background		 B6.NOD-Idd3NOD Idd10NOD/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idd10NOD/ShiLt mutation (2 available); any Idd10 mutation (10 available)
Idd3NOD mutation (2 available); any Idd3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK T cell physiology ( J:85823 )
• decreased cytokine response of iNKT cells when stimulated with antigens
abnormal cytokine secretion ( J:85823 )
• decreased cytokine response (IL-2, IL-4, IFN-gamma, CSF-1) of iNKT cells when stimulated with antigens

hematopoietic system
abnormal NK T cell physiology ( J:85823 )
• decreased cytokine response of iNKT cells when stimulated with antigens




Genotype
MGI:3036829
ot2
Allelic
Composition		 Idd3NOD/?
Genetic
Background		 involves: C57BL/10 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idd3NOD mutation (2 available); any Idd3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreas inflammation ( J:17906 )
• susceptibility to insulitis

homeostasis/metabolism
abnormal glucose homeostasis ( J:3351 , J:17906 )
• susceptibility to type 1 diabetes (J:3351)

immune system
pancreas inflammation ( J:17906 )
• susceptibility to insulitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory