Phenotypes associated with this allele

• Allele Symbol: Idd3^C57BL/6
• Allele Name: C57BL/6
• Allele ID: MGI:2389019
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Idd3^C57BL/6/Idd3^C57BL/6	involves: C57BL/6 * NOD	MGI:2674232
hm2	Idd3^C57BL/6/Idd3^C57BL/6	NOD.B6-Idd3^C57BL/6	MGI:3623819
cx3	Idd3^C57BL/6/Idd3^C57BL/6 Idd5^C57BL/10SnJ/Idd5^C57BL/10SnJ	involves: C57BL/6 * C57BL/10SnJ * NOD	MGI:2674234
cx4	Idd10^C57BL/6J/Idd10^C57BL/6J Idd3^C57BL/6/Idd3^C57BL/6	involves: C57BL/6 * NOD	MGI:3038854
cx5	Aire^tm1.1Doi/Aire^tm1.1Doi Idd3^C57BL/6/Idd3^C57BL/6 Idd5^C57BL/10SnJ/Idd5^C57BL/10SnJ	NOD.Cg-Idd3^C57BL/6 Idd5^C57BL/10SnJ Aire^tm1.1Doi/Doi	MGI:3793705

Genotype
MGI:2674232

hm1

• Allelic Composition: Idd3^C57BL/6/Idd3^C57BL/6
• Genetic Background: involves: C57BL/6 * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:52572 )

• resistance to insulin dependent diabetes

Genotype
MGI:3623819

hm2

• Allelic Composition: Idd3^C57BL/6/Idd3^C57BL/6
• Genetic Background: NOD.B6-Idd3^C57BL/6

homeostasis/metabolism

abnormal glucose homeostasis ( J:108210 )

• resistance to insulin-dependent diabetes

immune system

decreased susceptibility to autoimmune diabetes ( J:120349 )

• resistance to type 1 diabetes

Genotype
MGI:2674234

cx3

• Allelic Composition: Idd3^C57BL/6/Idd3^C57BL/6; Idd5^C57BL/10SnJ/Idd5^C57BL/10SnJ
• Genetic Background: involves: C57BL/6 * C57BL/10SnJ * NOD

homeostasis/metabolism

abnormal glucose homeostasis ( J:71276 )

• partial reversal of autoimmune exocrinopathy markers

Genotype
MGI:3038854

cx4

• Allelic Composition: Idd10^C57BL/6J/Idd10^C57BL/6J; Idd3^C57BL/6/Idd3^C57BL/6
• Genetic Background: involves: C57BL/6 * NOD

homeostasis/metabolism

abnormal glucose homeostasis ( J:42103 )

• resistance to type 1 diabetes

Genotype
MGI:3793705

cx5

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi; Idd3^C57BL/6/Idd3^C57BL/6; Idd5^C57BL/10SnJ/Idd5^C57BL/10SnJ
• Genetic Background: NOD.Cg-Idd3^C57BL/6 Idd5^C57BL/10SnJ Aire^tm1.1Doi/Doi

immune system

stomach inflammation ( J:107432 )

digestive/alimentary system

stomach inflammation ( J:107432 )

endocrine/exocrine glands

abnormal pancreas physiology ( J:107432 )

• Background Sensitivity: the pancreatitis associated with the Aire^tm1.1Doi allele on the NOD background is much less severe when these alleles of Idd3 and Idd5 are present

• Background Sensitivity: the gastritis associated with the Aire^tm1.1Doi allele on the NOD background is much less severe when these alleles of Idd3 and Idd5 are present