Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-ADRBK1)12Wjk
• Allele Name: transgene insertion 12, Walter Koch
• Allele ID: MGI:2389028
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-ADRBK1)12Wjk/0 Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * SJL	MGI:3799351
tg2	Tg(Myh6-ADRBK1)12Wjk/?	involves: C57BL/6 * SJL	MGI:3799313

Genotype
MGI:3799351

cx1

• Allelic Composition: Tg(Myh6-ADRBK1)12Wjk/0; Tg(Myh6-ADRBK1)27Wjk/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:127858 )

N • both the left ventricular dP/dTmin and dP/dTmax are normal at baseline and respond normally to the beta-agonist isoproterenol

Genotype
MGI:3799313

tg2

• Allelic Composition: Tg(Myh6-ADRBK1)12Wjk/?
• Genetic Background: involves: C57BL/6 * SJL

cardiovascular system

increased left ventricle diastolic pressure ( J:37034 , J:127858 )

• there is a blunted response to rises in pressure induced by the beta-agonist isoproterenol (J:37034)

• rises in pressure induced by the beta-agonist isoproterenol are depressed in these mice by about 20% at the highest dose (J:127858)

abnormal heart rate ( J:37034 )

• heart rate failed to increase in response to the beta-agonist isoproterenol

• rises in pressure induced by the beta-agonist isoproterenol are depressed in these mice by about 20% at the highest dose