Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-ADRBK1)27Wjk
• Allele Name: transgene insertion 27, Walter Koch
• Allele ID: MGI:2389030
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6*)140Lnwd/0 Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * CBA * SJL	MGI:3799197
cx2	Csrp3^tm1Crni/Csrp3^tm1Crni Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * SJL	MGI:3037429
cx3	Tg(Myh6-ADRBK1)12Wjk/0 Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * SJL	MGI:3799351
tg4	Tg(Myh6-ADRBK1)27Wjk/0	involves: C57BL/6 * SJL	MGI:3799196

Genotype
MGI:3799197

cx1

• Allelic Composition: Tg(Myh6*)140Lnwd/0; Tg(Myh6-ADRBK1)27Wjk/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:134706 )

• fibrosis and cellular disarray are apparent to variable extent at 8 months of age

growth/size/body

cardiac hypertrophy ( J:134706 )

• fibrosis and cellular disarray are apparent to variable extent at 8 months of age

Genotype
MGI:3037429

cx2

• Allelic Composition: Csrp3^tm1Crni/Csrp3^tm1Crni; Tg(Myh6-ADRBK1)27Wjk/0
• Genetic Background: involves: C57BL/6 * SJL

cardiovascular system

cardiovascular system phenotype ( J:48062 , J:66250 )

N • partial rescue of the dilated cardiomyopathic phenotype observed in Csrp3^tm1Crni homozygotes, with some persistence of decreased contractility and fibrosis (J:48062)

N • no observed ventricular dilation (J:48062)

N • cellular and whole heart function is restored to normal (J:66250)

cardiac interstitial fibrosis ( J:48062 )

decreased heart ventricle muscle contractility ( J:48062 )

• relative to wild-type

• partial rescue of decreased contractility observed in Csrp3^tm1Crni homozygotes

muscle

decreased heart ventricle muscle contractility ( J:48062 )

• relative to wild-type

• partial rescue of decreased contractility observed in Csrp3^tm1Crni homozygotes

cellular

cardiac interstitial fibrosis ( J:48062 )

Genotype
MGI:3799351

cx3

• Allelic Composition: Tg(Myh6-ADRBK1)12Wjk/0; Tg(Myh6-ADRBK1)27Wjk/0
• Genetic Background: involves: C57BL/6 * SJL

cardiovascular system

cardiovascular system phenotype ( J:127858 )

N • both the left ventricular dP/dTmin and dP/dTmax are normal at baseline and respond normally to the beta-agonist isoproterenol

Genotype
MGI:3799196

tg4

• Allelic Composition: Tg(Myh6-ADRBK1)27Wjk/0
• Genetic Background: involves: C57BL/6 * SJL

cardiovascular system

increased cardiac muscle contractility ( J:134706 )

• mice have increased fractional shortening from 4 to at least 12 months of age

increased left ventricle diastolic pressure ( J:37034 , J:127858 )

• both the left ventricular dP/dTmin and dP/dTmax are significantly increased at baseline (J:37034)

• increases in pressure are enhanced with administration of the beta-agonist isoproterenol (J:37034)

• both the left ventricular dP/dTmin and dP/dTmax are significantly increased about 25% at baseline (J:127858)

• increases in pressure are enhanced with administration of the beta-agonist isoproterenol (J:127858)

increased left ventricle systolic pressure ( J:37034 )

• left ventricular systolic pressure is increased at baseline

• increases in pressure are enhanced with administration of the beta-agonist isoproterenol

muscle

increased cardiac muscle contractility ( J:134706 )

• mice have increased fractional shortening from 4 to at least 12 months of age