Analysis Tools
neoplasm
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• soft tissue tumors; tumors were distributed over the entire body surface, but were more frequents in the subcutaneous tissues along the flank and the back of the neck, and to a lesser extent the intraperitoneal soft tissues
• incidence of subcutaneous tumors was greater than 50%
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• tumors were histologically and pathologically characterized as mixed sacromas
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preneoplasia
(
J:36423
)
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• significant but variable frequency of neoplasia was observed in the kidney, adrenal gland, testis, and submandibular gland at sites of known Ren2 expression
• neoplasia included mild to severe cellular hyperplasia and tumor formation in several cases
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renal/urinary system
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• severe vascular lesions manifested by marked atypical hyperplasia of the vascular smooth muscle were noted in mice 12-16 weeks of age
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cardiovascular system
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• severe vascular lesions manifested by marked atypical hyperplasia of the vascular smooth muscle were noted in mice 12-16 weeks of age
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