Phenotypes associated with this allele

• Allele Symbol: Hoxd11^{tm2.1(Hoxd11)Mrc}
• Allele Name: targeted mutation 2.1, Mario R Capecchi
• Allele ID: MGI:2389127
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd11^tm2.1(Hoxd11)Mrc/Hoxd11^tm2.1(Hoxd11)Mrc	involves: BALB/cJ	MGI:3810832
ht2	Hoxd11^tm2.1(Hoxd11)Mrc/Hoxd11^+	involves: BALB/cJ	MGI:3810833
ht3	Hoxd11^tm1Mrc/Hoxd11^tm2.1(Hoxd11)Mrc	involves: BALB/cJ	MGI:3810834
cx4	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm2.1(Hoxd11)Mrc	involves: 129S7/SvEvBrd * BALB/cJ	MGI:3810836
cx5	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm2.1(Hoxd11)Mrc/Hoxd11^+	involves: BALB/cJ	MGI:3810830
cx6	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm2.1(Hoxd11)Mrc/Hoxd11^tm2.1(Hoxd11)Mrc	involves: BALB/cJ	MGI:3810831
cx7	Hoxa11^tm1Mrc/Hoxa11^+ Hoxd11^tm2.1(Hoxd11)Mrc/Hoxd11^tm2.1(Hoxd11)Mrc	involves: BALB/cJ	MGI:3810839

Genotype
MGI:3810832

hm1

• Allelic Composition: Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal phalanx morphology ( J:78766 )

• the length of the phalanges 1 and 2 of digit II relative to the length of the humerus is increased compared to in wild-type mice

elongated metacarpal bones ( J:78766 )

• the length of digits II, III and IV relative to the length of the humerus is increased compared to in wild-type mice

decreased lumbar vertebrae number ( J:78766 )

• 5 instead of 6

limbs/digits/tail

abnormal phalanx morphology ( J:78766 )

• the length of the phalanges 1 and 2 of digit II relative to the length of the humerus is increased compared to in wild-type mice

elongated metacarpal bones ( J:78766 )

• the length of digits II, III and IV relative to the length of the humerus is increased compared to in wild-type mice

Genotype
MGI:3810833

ht2

• Allelic Composition: Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺
• Genetic Background: involves: BALB/cJ

skeleton

decreased lumbar vertebrae number ( J:78766 )

• 5 instead of 6

Genotype
MGI:3810834

ht3

• Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}
• Genetic Background: involves: BALB/cJ

skeleton

skeleton phenotype ( J:78766 )

N • mice exhibit a normal number of lumbar vertebrae

Genotype
MGI:3810836

cx4

• Allelic Composition: Hoxa11^tm1Mrc/Hoxa11^tm1Mrc; Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}
• Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

skeleton

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

limbs/digits/tail

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

Genotype
MGI:3810830

cx5

• Allelic Composition: Hoxa11^tm1Mrc/Hoxa11^tm1Mrc; Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺
• Genetic Background: involves: BALB/cJ

reproductive system

female infertility ( J:78766 )

♀

reduced male fertility ( J:78766 )

♂ • 4 of 10 mice are fertile

skeleton

skeleton phenotype ( J:78766 )

N • mice exhibit a normal number of lumbar vertebrae

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

Genotype
MGI:3810831

cx6

• Allelic Composition: Hoxa11^tm1Mrc/Hoxa11^tm1Mrc; Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
• Genetic Background: involves: BALB/cJ

reproductive system

female infertility ( J:78766 )

♀

male infertility ( J:78766 )

♂

skeleton

skeleton phenotype ( J:78766 )

N • mice exhibit a normal number of lumbar vertebrae

limbs/digits/tail

limbs/digits/tail phenotype ( J:78766 )

N • forearm bones are normal

Genotype
MGI:3810839

cx7

• Allelic Composition: Hoxa11^tm1Mrc/Hoxa11⁺; Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
• Genetic Background: involves: BALB/cJ

skeleton

skeleton phenotype ( J:78766 )

N • mice exhibit a normal number of lumbar vertebrae