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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blnktm1Achn
targeted mutation 1, Andrew C Chan
MGI:2389137
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Blnktm1Achn/Blnktm1Achn involves: 129X1/SvJ MGI:3836560
ht2
 		Blnktm1Achn/Blnk+ involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 MGI:3836564
cx3
 		Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0 		involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 MGI:3836561


Genotype
MGI:3836560
hm1
Allelic
Composition		 Blnktm1Achn/Blnktm1Achn
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:58805 )
• splenic B cells are larger in size and express higher membrane IgM levels indicating a defect in maturation to the B220hiIgMloIgDhi stage
increased pro-B cell number ( J:58805 )
• accumulate B220+CD43+ pro-B cells
arrested B cell differentiation ( J:58805 )
• profound block in B cell development
• cells fail to progress efficiently from the immature stage to the transitional stage
decreased mature B cell number ( J:58805 )
• decrease in IgM+ peripheral B cells in the spleen and a marked reduction in B220hiIgM+ and IgMloIgDhi B cells in the bone marrow and periphery, respectively
• older mice have increased numbers of B220+ IgM+ B cells compared to younger mice but the numbers are still more than 10 times lower than in age matched controls
abnormal mature B cell morphology ( J:58805 )
• the few IgM+ peripheral B cells that are present are larger in size compared to controls
absent B-1b cells ( J:58805 )
• absent from the spleen and peritoneum
decreased splenocyte number ( J:58805 )
• a 65% reduction in splenocyte numbers

cardiovascular system
cardiovascular system phenotype ( J:58805 )
N
• despite the occurrence of hemorrhages in mice null for related proteins, no signs of gross hemorrhage are seen in these mice

hematopoietic system
abnormal B cell differentiation ( J:58805 )
• splenic B cells are larger in size and express higher membrane IgM levels indicating a defect in maturation to the B220hiIgMloIgDhi stage
increased pro-B cell number ( J:58805 )
• accumulate B220+CD43+ pro-B cells
arrested B cell differentiation ( J:58805 )
• profound block in B cell development
• cells fail to progress efficiently from the immature stage to the transitional stage
decreased mature B cell number ( J:58805 )
• decrease in IgM+ peripheral B cells in the spleen and a marked reduction in B220hiIgM+ and IgMloIgDhi B cells in the bone marrow and periphery, respectively
• older mice have increased numbers of B220+ IgM+ B cells compared to younger mice but the numbers are still more than 10 times lower than in age matched controls
absent B-1b cells ( J:58805 )
• absent from the spleen and peritoneum
abnormal mature B cell morphology ( J:58805 )
• the few IgM+ peripheral B cells that are present are larger in size compared to controls
decreased splenocyte number ( J:58805 )
• a 65% reduction in splenocyte numbers




Genotype
MGI:3836564
ht2
Allelic
Composition		 Blnktm1Achn/Blnk+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased




Genotype
MGI:3836561
cx3
Allelic
Composition		 Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (78 available)
Btktm1Wk mutation (1 available); any Btk mutation (21 available)
Tg(IGH-Btk)1Witt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased




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11/12/2024
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